Publications by authors named "Luigi Valdenassi"
The action of ozone in medicine is a subject of interest and lively, controversial debates. Its mechanisms of action are still far from fully understood. However, it is possible that ozone triggers a series of dynamics in living organisms related to chaos, multi-stable phenomena, and oscillatory processes.
View Article and Find Full Text PDFOxygen-ozone therapy has garnered increasing attention for its potential therapeutic applications, yet its widespread adoption is hindered by inconsistent protocols and a lack of standardized guidelines. Standardizing these protocols is essential to ensure the safety, efficacy, and reproducibility of treatments. Advanced training for physicians and caregivers is paramount, equipping them with evidence-based knowledge and practical expertise to administer this therapy effectively while avoiding unverified or misleading innovative approaches.
View Article and Find Full Text PDFBackground: Infections caused by the Aspergillus genus are relatively uncommon and typically associated with hospitalization, while only a few cases are linked to environmental exposure to filamentous moulds. These infections can significantly impact pulmonary function, and antifungal therapy may further compromise lung physiology, especially if fungal nodules develop. Consequently, many cases of aspergillosis are not directly treated to avoid additional lung damage.
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- Cardiovascular diseases (CVDs) are a serious global health issue, prompting extensive research focused on prevention through lifestyle changes, diet, and improved medical knowledge.
- Ozone therapy is gaining attention as it stimulates the endothelial nitric oxide synthase/nitric oxide pathway, potentially offering new treatment options to mitigate endothelial and cardiac problems related to CVDs, such as atrial fibrillation.
- This review aims to outline effective methods for using ozone in treating cardiovascular issues, particularly acute myocardial infarction from ischemic conditions, and emphasizes the need for further research in this area.
Article Synopsis
- - Knee osteoarthritis (OA) is a chronic condition that causes pain, stiffness, and difficulty moving the knee joint, and current treatments like platelet-rich plasma and hyaluronic acid have shown limited effects on managing symptoms.
- - A recent study explored the effectiveness of ozonated blood infusions for treating knee OA, finding that 250 patients showed approximately a 50% improvement in their health status after only five treatment sessions.
- - The ozone therapy significantly reduced pain, disability, and stiffness, with positive outcomes reflected through WOMAC and Lequesne functional indexes for both men and women with varying severity of knee OA.
Article Synopsis
- * Two clinical studies demonstrated the effectiveness of ozone in treating infected post-surgical wounds and knee osteoarthritis, with notable reductions in infection and inflammation.
- * The findings suggest that ozone therapy can enhance immune response, promote bacterial clearance, and alleviate symptoms in patients with specific conditions.
Article Synopsis
- * It operates on the principle of hormesis at low doses, promoting cell protection through the activation of the body's antioxidant systems and having anti-inflammatory effects.
- * As a bioregulator, ozone enhances mitochondrial function and influences complex regulatory mechanisms in cells, making it a novel approach in pharmacology and medical treatments.
Article Synopsis
- - Ozone, a form of oxygen, is being researched for its potential to help treat bacterial infections in wounds, especially those caused by drug-resistant bacteria.
- - It works by activating a protein called Nrf2, which initiates a series of biological responses that enhance the function of immune cells known as macrophages in clearing infections.
- - This review focuses on the latest findings regarding how ozone influences immune responses and its effectiveness against both regular and multidrug-resistant bacteria.