Publications by authors named "Luigi M Coppola"
Article Synopsis
- AA-amyloidosis is a common issue in shelter cats, leading to chronic kidney disease, which is the primary cause of death in these animals.* -
- A study analyzed kidney samples from 9 domestic short-hair cats (median age 8 years) post-mortem, revealing all had elevated serum creatinine, proteinuria, and amyloid deposits in both the cortex and medulla.* -
- The findings indicate systemic AA-amyloidosis is prevalent in shelter cats with chronic kidney disease, suggesting these cats can serve as a natural model for studying this condition.*
Article Synopsis
- Systemic AA-amyloidosis is a disease caused by the misfolding of serum amyloid-A protein, leading to its accumulation in various organs; this condition is seen in both humans and animals, including cheetahs and certain domestic cat breeds.
- A study conducted in three shelters found that AA-amyloidosis had high prevalence rates (52.0% to 73.0%) among the shelter cats examined, with many affected cats showing damage in multiple organs.
- The research suggested a potential link between longer shelter stays and more severe amyloidosis, indicating that shelter cats could serve as a natural model for studying this disease and hinting at possible fecal-oral transmission routes through the presence of SAA fragments
Background: Feline panleukopenia virus (FPV) is very resistant and highly contagious and infects domestic cats and other felids. FPV is particularly widespread among sheltered cats, and is associated with high morbidity and mortality, causing severe gastroenteritis characterized by anorexia, lethargy, fever, dehydration, hemorrhagic diarrhea, and vomiting. There is currently no data on the ultrasonographic features of cats affected with FPV.
View Article and Find Full Text PDFFeline parvovirus (FPV) causes severe gastroenteritis and leukopenia in cats; the outcome is poor. Information regarding specific treatments is lacking. Class A CpG oligodeoxynucleotides (CpG-A) are short single-stranded DNAs, stimulating type I interferon production.
View Article and Find Full Text PDFA diabetic cat was referred because of poor metabolic control and difficulties the owner experienced injecting insulin. A pump, telemetrically controlled with a smartphone, was implanted subcutaneously to deliver insulin. Before implantation, the pump reservoir was filled with a rapid-acting human recombinant insulin.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) has typically a non-immune mediated origin in cats and immune-complex glomerulonephritis (ICGN) is scarcely described. Aims of this study were to characterize ICGN by light and electron microscopy and identify associations with clinico-pathological findings. In addition, comparisons between cats with ICGN and non immune-complex glomerulonephritis (non-ICGN) were performed.
View Article and Find Full Text PDFObjective: To determine overall survival time and identify prognostic factors associated with survival time in cats with newly diagnosed diabetes mellitus.
Design: Retrospective case series.
Animals: 114 cats with newly diagnosed diabetes mellitus.