High order expression dependencies finely resolve cryptic states and subtypes in single cell data.

Single cells are typically typed by clustering into discrete locations in reduced dimensional transcriptome space. Here we introduce Stator, a data-driven method that identifies cell (sub)types and states without relying on cells' local proximity in transcriptome space. Stator labels the same single cell multiply, not just by type and subtype, but also by state such as activation, maturity or cell cycle sub-phase, through deriving higher-order gene expression dependencies from a sparse gene-by-cell expression matrix.

Lessons learned from urgent computing in Europe: Tackling the COVID-19 pandemic.

PRACE (Partnership for Advanced Computing in Europe), an international not-for-profit association that brings together the five largest European supercomputing centers and involves 26 European countries, has allocated more than half a billion core hours to computer simulations to fight the COVID-19 pandemic. Alongside experiments, these simulations are a pillar of research to assess the risks of different scenarios and investigate mitigation strategies. While the world deals with the subsequent waves of the pandemic, we present a reflection on the use of urgent supercomputing for global societal challenges and crisis management.

Nonperturbative Infrared Finiteness in a Superrenormalizable Scalar Quantum Field Theory.

We present a study of the IR behavior of a three-dimensional superrenormalizable quantum field theory consisting of a scalar field in the adjoint of SU(N) with a φ^{4} interaction. A bare mass is required for the theory to be massless at the quantum level. In perturbation theory, the critical mass is ambiguous due to IR divergences, and we indeed find that at two loops in lattice perturbation theory the critical mass diverges logarithmically.

Precision determination of the strong coupling constant within a global PDF analysis: NNPDF Collaboration.

We present a determination of the strong coupling constant based on the NNPDF3.1 determination of parton distributions, which for the first time includes constraints from jet production, top-quark pair differential distributions, and the distributions using exact NNLO theory. Our result is based on a novel extension of the NNPDF methodology - the correlated replica method - which allows for a simultaneous determination of and the PDFs with all correlations between them fully taken into account.

Parton distributions from high-precision collider data: NNPDF Collaboration.

We present a new set of parton distributions, NNPDF3.1, which updates NNPDF3.0, the first global set of PDFs determined using a methodology validated by a closure test.

Topological susceptibility in SU(3) gauge theory.

We compute the topological susceptibility for the SU(3) Yang-Mills theory by employing the expression of the topological charge density operator suggested by Neuberger's fermions. In the continuum limit we find r(4)(0)chi = 0.059(3), which corresponds to chi = (191 +/- 5 MeV)(4) if F(K) is used to set the scale.