A (sub)graph isomorphism algorithm for matching large graphs.

We present an algorithm for graph isomorphism and subgraph isomorphism suited for dealing with large graphs. A first version of the algorithm has been presented in a previous paper, where we examined its performance for the isomorphism of small and medium size graphs. The algorithm is improved here to reduce its spatial complexity and to achieve a better performance on large graphs; its features are analyzed in detail with special reference to time and memory requirements.

Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: a randomized, double-blind, placebo-controlled trial.

Purpose: We performed a randomized, double-blind, placebo-controlled trial to assess the efficacy of glutathione (GSH) in the prevention of oxaliplatin-induced neurotoxicity.

Patients And Methods: Fifty-two patients treated with a bimonthly oxaliplatin-based regimen were randomized to receive GSH (1,500 mg/m(2) over a 15-minute infusion period before oxaliplatin) or normal saline solution. Clinical neurologic evaluation and electrophysiologic investigations were performed at baseline and after four (oxaliplatin dose, 400 mg/m(2)), eight (oxaliplatin dose, 800 mg/m(2)), and 12 (oxaliplatin dose, 1,200 mg/m(2)) cycles of treatment.