Publications by authors named "Luigi Castorani"
Discovering novel risk and prognostic factors for COVID-19 may help not only in reducing severity and mortality but also in creating targeted therapies considering patients’ individual features. Liver fibrosis is considered a complication in Non-alcoholic Fatty Liver Disease (NAFLD), it is a feature of steatohepatitis (NASH), and it has already been related to an increased risk for a wide range of diseases. Here, we aimed to define if any parameter assessing metabolic status has predictive power in identifying inpatients at risk for poorer prognosis and an increased mortality from COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- Latrodectism is a serious syndrome caused by bites from Latrodectus spiders, particularly L. tredecimguttatus, which is found in Italy and releases toxins affecting motor and adrenergic nerve function.
- A 60-year-old man experienced severe symptoms after being bitten in the leg, leading to a hyperacute emergency presentation that included agitation, sweating, and muscle spasms, ultimately identified as poisoning from L. tredecimguttatus.
- The patient was treated successfully with L. mactans antivenom from North America, showing significant improvement within an hour and being discharged two days later, highlighting the importance of prompt diagnosis and treatment for latrodectism.
The liver plays a pivotal role in a myriad of metabolic processes, including detoxification, glycolipidic storage and export, and protein synthesis. Breath tests employing (13)C as stable isotope have been introduced to explore such energy-dependent pathways involving mitochondrial function in the liver. Specific substrates are ketoisocaproic acid, methionine, and octanoic acid.
View Article and Find Full Text PDFConcomitant, sequential, and hybrid therapy for H. pylori eradication: a pilot study.
Clin Res Hepatol Gastroenterol
December 2013
Background And Objective: Since the efficacy of the standard triple therapies for Helicobacter pylori eradication has decreased, novel antibiotic regimens have been introduced, including concomitant, sequential, and hybrid therapies. We aimed to compare the cure rates achieved by these new therapy regimens.
Methods: This was a multicenter, open-label, pilot study enrolling consecutive non-ulcer dyspepsia patients with H.