Relationship between the sonographic appearance of the thyroid and the clinical course and autoimmune activity of Graves' disease.

Purpose: The aim of this study was to investigate the relationship between thyroid echogenicity and clinical course/immunologic parameters in Graves' disease.

Methods: Two hundred and six outpatients with Graves' disease (31 men, 175 women; 46 +/- 23 years old) were studied with thyroid sonography and color Doppler sonography. Forty-five patients were treated for active hyperthyroidism, 161 were euthyroid (85 immediately before withdrawal of antithyroid drug at maintenance doses, 76 in stable remission after withdrawal of antithyroid treatment).

A singular case of Graves' disease in congenital thyroid hemiagenesis.

We report the observation of an unusual case of Graves' disease associated with thyroid hemiagenesis. A 41-year-old woman who presented with symptoms and clinical signs of hyperthyroidism was discovered to have thyroid hemiagenesia of the left lobe. Thyroid ultrasound scan showed enlargement of the right lobe with a single nodule, and absence of the left lobe; isotope scan showed homogeneous uptake in the single lobe and nodule.

Autocrine inhibitory influences of alpha-melanocyte-stimulating hormone in malignant pleural mesothelioma.

Malignant pleural mesothelioma is a highly aggressive tumor arising from the mesothelial cells that line the pleural cavities. This tumor is resistant to most conventional anticancer treatments and appears to be very sensitive to growth-promoting influences of cytokines and growth factors. Identification of natural inhibitory pathways that control growth should aid discovery of novel therapeutic approaches.