Publications by authors named "Luigi Annicchiarico Petruzzelli"

Article Synopsis
  • Researchers looked at children in Italy who were hospitalized for a urinary infection and checked their sodium (Na) and potassium (K) levels.
  • They found that 23% of the kids had low sodium, while some had high potassium or both low sodium and high potassium.
  • The study also discovered that specific levels in the blood and age were linked to these imbalances, with the most common issue being low sodium.
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Article Synopsis
  • The study aimed to assess the prevalence and risk factors for acute kidney injury (AKI) in children hospitalized for febrile urinary tract infections (fUTI), and to determine if AKI could indicate underlying vesicoureteral reflux (VUR).
  • Out of 849 children studied, 14.6% developed AKI, with a higher prevalence of 30% in those having congenital anomalies of the kidney and urinary tract (CAKUT).
  • AKI was identified as a strong predictor for VUR, even after accounting for other diagnostic factors, indicating its relevance in evaluating children with fUTI.
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Pathogenic variants in the gene cause rare and severe X-linked dominant hypophosphataemia (XLH), a form of heritable hypophosphatemic rickets (HR) characterized by renal phosphate wasting and elevated fibroblast growth factor 23 (FGF23) levels. Burosumab, the approved human monoclonal anti-FGF23 antibody, is the treatment of choice for XLH. The genetic and phenotypic heterogeneity of HR often delays XLH diagnoses, with critical effects on disease course and therapy.

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The global coronavirus 2019 (COVID-19) pandemic required vaccination even in children to reduce infection. We report on the development of acute kidney injury (AKI) and minimal change disease (MCD) nephrotic syndrome (NS), shortly after the first injection BNT162b2 COVID-19 vaccine (Pfizer-BioNTech). A 12-year-old previously healthy boy was referred to our hospital with complaints of peripheral edema and nephrotic range proteinuria.

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Purpose: Fabry Disease (FD) has been frequently proposed as possible underestimated differential diagnosis of Multiple Sclerosis (MS), but no study has been performed to test prevalence of GLA gene mutations in a population fulfilling diagnostic criteria of MS. Aim of this study is to determine the prevalence of GLA gene mutations in a large and representative population diagnosed with MS, simultaneously providing a critical revision of current literature reports of coexistence or misdiagnosis between these two conditions.

Methods: In this mono-centric cross-sectional study, 927 patients fulfilling McDonald diagnostic criteria and encompassing all MS phenotypes were enrolled.

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Background: Oral iron is recommended as first line treatment of anemia in non-dialysis chronic kidney disease (ND-CKD) patients. Sucrosomial® iron, a new generation oral iron with high absorption and bioavailability and a low incidence of side effects, has shown to be not inferior to intravenous (IV) iron in the replacement of iron deficiency anemia in patients with ND-CKD. Besides the clinical benefit, it is also important to determine the comparative total costs of oral versus IV iron administrations.

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Background: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disease characterized by the presence of renal cysts. Over time the expanding cysts lead to progressive renal failure. The use of tolvaptan, a V-receptor antagonist, was recently approved in ADPKD patients.

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Background And Objectives: Progressive nephropathy is one of the main features of Fabry disease (FD). It has been supposed that an early phase, clinically silent disease occurs in childhood and adolescence and is characterized by glomerular hyperfiltration (HF). Surprisingly, although HF has been reported in several studies, its prevalence is at present unknown.

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