Publications by authors named "Luigi A Warren"
Article Synopsis
- Hematopoietic stem cells (HSCs) in the bone marrow must constantly replenish blood effector cells, but it's unclear if their replicative potential limits their lifespan in normal aging.
- Research shows that pathways involved in DNA repair, managing reactive oxygen species, and telomere maintenance are vital for the longevity of HSCs.
- As HSCs age, they tend to differentiate more towards myeloid cells, possibly leading to a decrease in lymphoid cell production, raising future research concerns about immune dysfunction and epigenetic changes in HSC aging.
Article Synopsis
- Cumulative somatic mutations may impact aging by disrupting the networks that control cell function and structure.
- A study on cardiomyocytes indicated that older cells showed increased transcriptional variability.
- However, research on four types of hematopoietic cells did not find significant age-related changes in gene expression noise or cell variability, suggesting that regulatory instability may be more relevant in nonrenewing tissues.
Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors.
Curr Opin Immunol
April 2003
During lymphopoiesis, precursor cells negotiate a complex regulatory space, defined by the levels of several competing and cross-regulating transcription factors, before arriving at stable states of commitment to the B-, T- and NK-specific developmental programs. Recent perturbation experiments provide evidence that this space has three major axes, corresponding to the PU.1 versus GATA-1 balance, the intensity of Notch signaling through the CSL pathway, and the ratio of E-box transcription factors to their Id protein antagonists.
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