Publications by authors named "Lui Jin Yao"
The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19.
Int Immunopharmacol
December 2021
Article Synopsis
- - The COVID-19 pandemic has highlighted how the body's immune response can go haywire, leading to severe health issues, including respiratory distress and multi-organ failure due to an overreaction known as cytokine storm syndrome.
- - The virus causes the immune system to produce excessive inflammatory substances, primarily through the activation of NF-kappa B (NF-κB), which contributes to the symptoms and complications of advanced COVID-19.
- - Potential treatments that target NF-κB, such as certain proteasome inhibitors, monoclonal antibodies, and corticosteroids, have shown promise in reducing severe outcomes in patients with COVID-19 by modulating the harmful immune response.
Article Synopsis
- * Uvaria species, found mainly in Southeast Asia's tropical rainforests, have a history of traditional medicinal use for various inflammatory conditions, supported by the presence of beneficial compounds such as flavonoids and tannins.
- * Research highlights the significant anti-inflammatory properties of specific Uvaria compounds, with recommendations for more studies on their pharmacological profiles and safety to potentially develop new anti-inflammatory treatments.
Ethnopharmacological Relevance: Polyalthia is one of the largest and notable genera in Annonaceae family. Polyalthia species have been widely used in folklore medicine for the treatment of rheumatic fever, gastrointestinal ulcer and generalized body pain. Numerous in vitro and in vivo studies on Polyalthia Species have also corroborated the significant anti-inflammatory potential of its extracts and secondary metabolites.
View Article and Find Full Text PDF