Publications by authors named "Luhua Ji"
Article Synopsis
- Mesenchymal stem cells (MSCs) show a specific tendency to move towards tumors, impacting cancer growth, treatment resistance, and immune response, prompting research into MSC-related biomarkers for better predicting bladder cancer outcomes.
- This study used data from TCGA and GSE31684 to identify genes linked to MSCs and created a risk assessment model through advanced statistical analysis techniques.
- The final prognostic model highlighted five key genes and classified bladder cancer patients into risk categories, revealing that high MSC-risk patients faced worse outcomes and lower responsiveness to immunotherapy and specific chemotherapy drugs compared to low MSC-risk patients.
The treatment of bladder cancer is limited by low drug efficacy and drug resistance. Hence, this study aimed to screen and identify potential drug precursors and investigate their mechanism of action. A set of camptothecin derivatives showing high anti-tumor potential was selected from early-stage research or literature and synthesized to construct a compound library.
View Article and Find Full Text PDFBackground: The current treatment strategy for metastatic Hormone-Sensitive Prostate Cancer (mHSPC) is the combination of Androgen Receptor Signaling Inhibitors (ARSIs) medicines with androgen deprivation therapy (ADT). However, there is a lack of real-world data comparing the efficacy of different ARSI pharmaceuticals. Therefore, the objective of this study was to compare the effectiveness and safety of bicalutamide, abiraterone, enzalutamide, and apalutamide in combination with ADT for patients with mHSPC.
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