Evaluation of ACE I/D and ATIR A1166C variants in patients with diabetes mellitus with and without peripheral neuropathy in Turkish patients.

Objective: Type 2 Diabetes Mellitus (T2DM) can lead to long-term vascular complications such as diabetic peripheral neuropathy (DPN). This study aimed to investigate the role of angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) and angiotensin II type 1 receptor (AT1R) A1166C variants in the predisposition to T2DM in the Turkish population and their association with DPN.

Methods: The study included 90 T2DM patients (42 with DPN) and 50 healthy individuals.

Double kissing crush versus culotte for bifurcation percutaneous coronary interventions: insights from the PROGRESS-BIFURCATION registry.

Background: Upfront 2-stent techniques are often used in bifurcation percutaneous coronary interventions (PCI), but there is controversy about optimal strategy selection.

Methods: The authors examined the clinical and angiographic characteristics and long-term outcomes of 232 bifurcation PCIs that were performed using the double kissing (DK) crush or culotte technique in 216 patients between 2014 and 2023 using data from the Prospective Global Registry for the Study of Bifurcation Lesion Interventions (NCT05100992). The inverse probability of treatment weighted (IPTW) Cox proportional hazards model was used to assess long-term outcomes.

Advanced Brain Tumor Classification in MR Images Using Transfer Learning and Pre-Trained Deep CNN Models.

Background/objectives: Brain tumor classification is a crucial task in medical diagnostics, as early and accurate detection can significantly improve patient outcomes. This study investigates the effectiveness of pre-trained deep learning models in classifying brain MRI images into four categories: Glioma, Meningioma, Pituitary, and No Tumor, aiming to enhance the diagnostic process through automation.

Methods: A publicly available Brain Tumor MRI dataset containing 7023 images was used in this research.

Noninvasive Approach to Postoperative Bleeding in Patients Undergoing Septorhinoplasty Surgery.

Objectives: In this study, we retrospectively examined the bleeding that occurred in the 5-year patient series.

Materials And Methods: One thousand seven hundred seventy-five patients who underwent septorhinoplasty surgery between 2019 and 2023 were included in the study, and 28 of these patients who presented with bleeding complications were examined. All patients underwent open-technique septorhinoplasty surgery with or without concha intervention and were discharged the next day after overnight hospitalization.

The Comparative Effects of Anakinra and Tocilizumab on Inflammation and Cerebral Vasospasm in an Experimental Subarachnoid Hemorrhage Model.

: Subarachnoid hemorrhage (SAH) is a life-threatening cerebrovascular condition that triggers a robust inflammatory response and cerebral vasospasm. This study aimed to evaluate the effects of anakinra, an interleukin-1 receptor antagonist, and tocilizumab, an interleukin-6 receptor antagonist, on inflammation and vasospasm in an experimental rat SAH model. : Forty male Sprague Dawley rats (200-250 g) were randomly assigned to five groups: control, SAH, SAH + anakinra (ANA), SAH + tocilizumab (TCZ), and SAH + anakinra + tocilizumab (ANA+TCZ).

Impact of the Abdominal Drawing-In Maneuver on Spinal Extensor Muscle Activity: A Randomized Controlled Double-Blind Trial Involving Individuals with Non-Specific Low Back Pain.

Non-specific low back pain (NSLBP) is a common musculoskeletal issue that can limit function and reduce the patient's quality of life. Enhancing spinal stabilizer muscle activity through targeted exercises may help improve spinal alignment and alleviate NSLBP symptoms. This study aimed to investigate whether incorporating the abdominal drawing-in maneuver (ADIM) into selected low back exercises influences the electromyographic (EMG) activity of key spinal extensor muscles.

Aneurysm Formation at the Internal Carotid Artery Bifurcation Is Related to the Vascular Geometry of the Bifurcation.

Background: In this study, we aimed to comparatively evaluate the morphology of internal carotid artery (ICA) bifurcations with and without aneurysms and identify risk factors for aneurysm development that are associated with the bifurcation geometry.

Method: In this two-center study, the computerized tomography angiography data of 1512 patients were evaluated. The study included 64 (4.

Electrochemical and Optical Multi-Detection of Through Magneto-Optic Nanoparticles: A Pencil-on-Paper Biosensor.

detection suffers from slow analysis time and high costs, along with the need for specificity. While state-of-the-art electrochemical biosensors are cost-efficient and easy to implement, their sensitivity and analysis time still require improvement. In this work, we present a paper-based electrochemical biosensor utilizing magnetic core-shell FeO@CdSe/ZnS quantum dots (MQDs) to achieve fast detection, low cost, and high sensitivity.

Bifurcation Percutaneous Coronary Intervention in Patients Aged ≥80 Years: Insights from the Prospective Global Registry for the Study of Bifurcation Lesion Interventions Registry.

The outcomes of bifurcation percutaneous coronary intervention (PCI) in patients aged ≥80 and ≥90 years have received limited study. We compared the procedural characteristics and outcomes of bifurcation PCIs in patients aged ≥80 years and those aged <80 years in a multicenter registry. Of 1,253 patients who underwent 1,262 bifurcation PCIs between 2014 and 2024 at 6 centers, 194 (15%) were aged ≥80 and ≥90 years.

Effects of immune modulatory treatment on language and psychiatric profile in patients with electrical status epilepticus in sleep (ESES).

Electrical status epilepticus in sleep (ESES) is an electrographic pattern associated with cognitive impairment. Our study aimed to prospectively evaluate the psychiatric findings and language skills in patients diagnosed with ESES and to determine the immune modulatory treatment-responsive subgroups. We assessed the patients for psychiatric features and language skills at the baseline and 12 months after.

Transauricular vagal nerve stimulation suppresses inflammatory responses in the gut and brain in an inflammatory bowel disease model.

Inflammatory bowel disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), is a major health problem on a global scale and its treatment is unsatisfactory. We aimed to investigate the effects of transauricular vagal nerve stimulation (tVNS) on inflammation in rats with IBD induced by trinitrobenzene sulfonic acid (TNBS). A total of 36 adult female Sprague-Dawley rats were given TNBS, or vehicle, and tVNS, or sham, every other day for 30 min for 10 days.

Synthetic Boosted Resampling Using Deep Generative Adversarial Networks: A Novel Approach to Improve Cancer Prediction from Imbalanced Datasets.

Background/objectives: This study examines the effectiveness of different resampling methods and classifier models for handling imbalanced datasets, with a specific focus on critical healthcare applications such as cancer diagnosis and prognosis.

Methods: To address the class imbalance issue, traditional sampling methods like SMOTE and ADASYN were replaced by Generative Adversarial Networks (GANs), which leverage deep neural network architectures to generate high-quality synthetic data. The study highlights the advantage of GANs in creating realistic, diverse, and homogeneous samples for the minority class, which plays a significant role in mitigating the diagnostic challenges posed by imbalanced data.

Multidimensional analysis of serving speed in volleyball players by position, sets, and league types: interactions and statistical differences.

Purpose: Our study explores the multifaceted factors influencing serve speed in volleyball, including player position, match progression, and league level, providing actionable insights for performance optimization and injury prevention strategies.

Methods: Using a cross-sectional approach, the study analyzes 15.347 serves from various leagues.

Memory under pressure: The impact of acute stress across different memory tasks.

In the present study, we aimed to investigate how acute stress exerts its heterogeneous effects. Based on biophysical network models, we hypothesized that acute stress would improve occipital-mediated ultra-short-term and to a lesser degree affect occipital- and frontal-mediated short-term and working, and impairs hippocampal-mediated long-term memory processes and their respective behavioral measures. To test this, 111 healthy individuals (57 female) underwent both the Trier Social Stress Test (TSST) and a control test.

TOTAL OXIDANT AND ANTIOXIDANT LEVELS IN PATIENTS WITH GALLBLADDER STONES OR RELATED COMPLICATIONS: ARE THEY IMPORTANT FOR TREATMENT?

Background: Many free radicals result in an inflammatory process due to complications caused by gallstones. These free radicals are inactivated by various reactions and participate in different reactions. Molecules are oxidants and antioxidants that take an active role in almost every event that takes place in the body.

Ruptured middle cerebral artery bifurcation aneurysms with concomitant intracerebral hematoma: Clinical and morphological risk factors.

The prognosis for intracerebral hematoma (ICH) following the rupture of a middle cerebral artery bifurcation (Mbif) aneurysm is poor. We compared patients with isolated diffuse subarachnoid hemorrhage (SAH) (without ICH) following Mbif aneurysm rupture to those with both SAH and ICH to evaluate clinical and morphological risk factors for ICH. A retrospective study was conducted on 112 patients with ruptured Mbif aneurysms treated between July 2016 and December 2021.

Fish: a new xenograft source for maxillary sinus lifting.

Objective: Although autogenous grafting is accepted as the gold standard in intraoral grafting, xenogenous grafts are frequently used in sinus lift surgeries due to their osteoinductive and osteoconductive properties. This study aimed to investigate the efficacy of fish spine-derived xenogenic grafts in sinus augmentation surgery.

Material And Methods: In this study, a fish spine-derived xenogenic graft was produced for comparison with autogenous graft and bovine derived xenogenic grafts.

The Effects of Carbohydrate Mouth Rinse on Psychophysiological Responses and Kinematic Profiles in Intermittent and Continuous Small-Sided Games in Adolescent Soccer Players: A Randomized, Double-Blinded, Placebo-Controlled, and Crossover Trial.

Background: Mouth rinsing (MR) with a carbohydrate solution is one of the most popular methods athletes use to improve their game-based performance due to its acute ergogenic effect.

Objectives: This study aimed to evaluate the effects of the carbohydrate MR intervention on psychophysiological responses and kinematic profiles during intermittent () and continuous () 4-a-side small-sided soccer games (SSGs).

Methods: Thirty-two adolescent soccer players (age: 16.

Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma.

FAK inhibitors are in combinatorial clinical testing with agents that prevent Ras-Raf-MAPK pathway activation in various cancers. This study suggests that nuclear FAK limits ERK/MAPK activation in supporting HGSOC cell survival to cisplatin stress. Overall, it is likely that targets of FAK-mediated survival signaling may be tumor type- and context-dependent.

Formulation and Evaluation of Triamcinolone Acetonide-Loaded Oral Disintegrated Film with Different Polymers Solvent Casting Method.

Objectives: The study aimed to investigate the effect of different polymers and plasticizers on oral disintegrating films (ODFs) containing triamcinolone acetonide (TA), a glucocorticosteroid indicated for the treatment of oral wounds.

Materials And Methods: Thirteen different formulations with the same amount of polymer and plasticizer were prepared by solvent casting. Briefly, the solutions containing polymer, plasticizer, and other ingredients were poured into Petri dishes and kept at room temperature for 20 hours to obtain ODFs.

ACR Appropriateness Criteria® Pretreatment Staging of Urothelial Cancer: 2024 Update.

Urothelial cancer is the second most common cancer, and cause of cancer death, related to the genitourinary tract. The goals of imaging for pretreatment staging of urothelial cancer are to evaluate for both local and distant spread of the cancer and assessing for synchronous sites of urothelial cancer in the upper tracts and bladder. For pretreatment staging of urothelial carcinoma, patients can be stratified into one of three groups: 1) nonmuscle invasive bladder cancer; 2) muscle invasive bladder cancer; and 3) upper urinary tract urothelial carcinoma.

Impact of Diabetes Mellitus on Bifurcation Percutaneous Coronary Intervention: Insights from the Prospective Global Registry for the Study of Bifurcation Lesion Interventions Registry.

The impact of diabetes mellitus (DM) on the outcomes of bifurcation percutaneous coronary intervention (PCI) has received limited study. We compared the procedural characteristics and outcomes of patients with and without DM in 1,302 bifurcation PCIs (1,147 patients) performed at 5 centers between 2013 and 2024. The prevalence of DM was 33.

Effects of 2 Combined Training Protocols on the Aerobic and Anaerobic Fitness, Technical Skills, and Psychophysiological Responses in Young Soccer Players.

Kilit, B, Chmura, P, Arslan, E, Soylu, Y, and Radziminski, Ł. Effects of 2 combined training protocols on the aerobic and anaerobic fitness, technical skills, and psychophysiological responses in young soccer players. J Strength Cond Res 39(1): 86-93, 2025-The study compared the effects of combining small-sided soccer games (SSGs) with high-intensity interval training (HIIT) and repeated sprint training (RST) on aerobic and anaerobic fitness, technical skills, and psychophysiological responses in young soccer players.

Wide-Based Columellar Strut Graft: A Novel Boost for Enhanced Nasal Tip Support in Ethnic and Revision Rhinoplasty.

Background: Adequate nasal tip support is crucial for achieving both aesthetic and functional outcomes in rhinoplasty. This study introduces a wide-based columellar strut graft (WB-columellar strut graft) as a new modification to provide enhanced support for the nasal tip, especially in challenging ethnic and revision rhinoplasty cases.

Objective: To present and evaluate the effectiveness of the WB-columellar strut graft in providing sufficient nasal tip support and achieving satisfactory aesthetic outcomes in patients with ethnic noses, Asian noses, and revision rhinoplasty cases presenting with weak caudal septum or anterior nasal spine.

Learning from Imbalanced Data: Integration of Advanced Resampling Techniques and Machine Learning Models for Enhanced Cancer Diagnosis and Prognosis.

Background/objectives: This study aims to evaluate the performance of various classification algorithms and resampling methods across multiple diagnostic and prognostic cancer datasets, addressing the challenges of class imbalance.

Methods: A total of five datasets were analyzed, including three diagnostic datasets (Wisconsin Breast Cancer Database, Cancer Prediction Dataset, Lung Cancer Detection Dataset) and two prognostic datasets (Seer Breast Cancer Dataset, Differentiated Thyroid Cancer Recurrence Dataset). Nineteen resampling methods from three categories were employed, and ten classifiers from four distinct categories were utilized for comparison.