Phytochemical screening and biological properties of Quintral flower polyphenolic fractions.

flower is used in traditional medicine for its antioxidant and antibacterial properties, which are attributed to phenolic compounds. These compounds present different grades of associations with the plant matrix (free, esterified, and insoluble). This study aimed to determine which fraction contributes the most to total phenolic and flavonoid contents and bioactive properties.

Nanostructured Conducting Polymers and Their Applications in Energy Storage Devices.

Due to the energy requirements for various human activities, and the need for a substantial change in the energy matrix, it is important to research and design new materials that allow the availability of appropriate technologies. In this sense, together with proposals that advocate a reduction in the conversion, storage, and feeding of clean energies, such as fuel cells and electrochemical capacitors energy consumption, there is an approach that is based on the development of better applications for and batteries. An alternative to commonly used inorganic materials is conducting polymers (CP).

Traumatic pseudoaneurysm in brachial artery after removal of a subdermal contraceptive implant.

The frequency of invasive therapeutic procedures has increased as medicine evolves, and the number of complications related to them has increased as a consequence. Subdermal contraceptive implants (SCI) offer benefits for female contraception, but implant and removal are associated with a complication rate of around 3%. In this article, we report and discuss a case of traumatic brachial artery pseudoaneurysm after an attempt to remove an SCI, complicated by compression of the median nerve.

The performance of truth: politicians, fact-checking journalism, and the struggle to tackle COVID-19 misinformation.

Since the World Health Organization (WHO, February 2, 2020) reported that the spread of coronavirus disease has been accompanied by a "massive infodemic," the COVID-19 outbreak has become a national and international battleground of a struggle against misinformation. Fact-checking outlets around the world have been actively counteracting false and misleading information surrounding the pandemic. In this article, we conceptualize fact checkers in terms of the "interpretative power" that journalism holds in processes of political performances (Alexander in Soc Theory 22(4): 527-573, 2004, in: The performance of politics.

Identifying Risk Profiles for Antisocial Behavior in a Spanish Sample of Young Offenders.

One of the main purposes of juvenile risk assessment is to distinguish different risk profiles, which may lead to referring youths into specific intervention programs tailored to their specific needs. This study is devoted to identifying main typologies of risk in a sample of 286 Spanish young offenders aged 14 to 22 ( = 17.36; = 1.

Automated Flow Cytometry: An Alternative to Urine Culture in a Routine Clinical Microbiology Laboratory?

The urine culture is the "gold standard" for the diagnosis of urinary tract infections (UTI) but constitutes a significant workload in the routine clinical laboratory. Due to the high percentage of negative results, there is a need for an efficient screening method, with a high negative predictive value (NPV) that could reduce the number of unnecessary culture tests. With the purpose of improving the efficiency of laboratory work, several methods for screening out the culture-negative samples have been developed, but none of them has shown adequate sensitivity (SE) and high NPV.

Recovering functional independence after a stroke through Modified Constraint-Induced Therapy.

Background: Population ageing and changes in the epidemiological profile of neurological pathologies has resulted in an increase in patients with disabilities. Rehabilitation strategies such as Modified Constraint-Induced Movement Therapy (CIMTm) play a key role in treating patients with neurologic deficiencies and motor impairments. This intervention is intended to mitigate disability, promote maximum functional independence, and optimize social and economic participation of patients with upper extremity weakness.

Prognostic Significance of Venous Thromboembolic Events in Disseminated Germ Cell Cancer Patients.

Background: Disseminated germ cell cancers are at high risk of developing thromboembolic complications. We evaluated the prognostic value of venous thromboembolic events (VTE) in disseminated germ cell cancer.

Methods: Patients with germ cell cancer receiving upfront platinum-containing chemotherapy between 2004 and 2014 were pooled from the Spanish Germ Cell Cancer Group (SGCCG) registry and reviewed for the presence of VTE.

Profiles of drug addicts in relation to personality variables and disorders.

In recent decades, research has identified a set of impulsive/disinhibited personality variables closely associated with drug addiction. As well as this, disorders linked with these variables, such as ADHD and personality disorders, are being closely studied in the field of drug addiction. Although much knowledge has been accumulated about the relation of these variables and disorders taken separately, less is known about how these constructs allow identify-specific profiles within the drug dependent population to be identified.

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.

The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages.

Regulation of CYBB Gene Expression in Human Phagocytes by a Distant Upstream NF-κB Binding Site.

The human CYBB gene encodes the gp91-phox component of the phagocyte oxidase enzyme complex, which is responsible for generating superoxide and other downstream reactive oxygen species essential to microbial killing. In the present study, we have identified by sequence analysis a putative NF-κB binding site in a DNase I hypersensitive site, termed HS-II, located in the distant 5' flanking region of the CYBB gene. Electrophoretic mobility assays showed binding of the sequence element by recombinant NF-κB protein p50 and by proteins in nuclear extract from the HL-60 myeloid leukemia cell line corresponding to p50 and to p50/p65 heterodimers.

[Expectations of relatives of critically ill patients regarding medical information. Qualitative research study].

Objective: To determine and analyse the expectations, needs and experiences of relatives of critically ill patients as regards medical information and the level of their understanding. To find keys for improving communication and to draw up best practices in clinical information.

Material And Methods: Qualitative research study through semi-structured interviews carried out in a polyvalent adult intensive care unit (ICU) in a University Hospital.

Sensation seeking and drunk driving: the mediational role of social norms and self-efficacy.

The aim of this work was to examine the role of sensation seeking in drunk driving by youths, and the potential mediational effect of social, cognitive and emotional variables on their relationship. To this end, a survey was conducted on 274 drivers (164 females and 110 males) aged 24.36±2.

A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates.

In multicellular organisms, cis-regulation controls gene expression in space and time. Despite the essential implication of cis-regulation in the development and evolution of organisms and in human diseases, our knowledge about regulatory sequences largely derives from analyzing their activity individually and outside their genomic context. Indeed, the contribution of these sequences to the expression of their target genes in their genomic context is still largely unknown.

Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective σ1 receptor ligands.

The synthesis and pharmacological activity of a new series of hexahydro-2H-pyrano[3,2-c]quinoline derivatives as potent σ1 receptor (σ1R) ligands are reported. This family, which does not contain the highly basic amino group usually present in other σ1R ligands, showed high selectivity over the σ2 receptor (σ2R). The activity was shown to reside in only one of the four possible diastereoisomers, which exhibited a perfect match with known σ1R pharmacophores.

Disentangling the role of psychopathic traits and externalizing behaviour in predicting conduct problems from childhood to adolescence.

Child and youth conduct problems are known to be a heterogeneous category that implies different factors and processes. The current study aims to analyze whether the early manifestation of psychopathic traits designates a group of children with severe, pervasive and persistent conduct problems. To this end, cluster analysis was conducted in a sample of 138 children (27.

Evaluation of micromorphological changes in tooth enamel after mechanical and ultrafast laser preparation of surface cavities.

The aim of this in vitro study was to evaluate the morphological changes that occur in tooth enamel after mechanical instrumentation and after femtosecond laser irradiation with different parameters via light and scanning electron microscopy (SEM). Twelve totally impacted third molars were collected and sectioned to provide several cut surfaces. These surfaces were exposed to infrared (λ = 795 nm, 120 fs, 1-kHz repetition rate, maximum mean power 1 W) laser pulses and machined by means of a conventional mechanical technique.

[Psychopathic personality as a distinctive indicator of severity and persistence for child and youth conduct problems].

Conduct problems are among the most discussed behavioral problems during childhood and adolescence. Given their heterogeneity, in recent years, researchers on this topic have called for delineation of early-onset conduct problems on the basis of affective, interpersonal and behavioral traits that resemble adult psychopathy. The present study aims to analyze, from both a cross-sectional and longitudinal perspective, whether early psychopathic traits allow identification of a group of individuals defined by severe and persistent behavioral problems.

A cross-national study of preadolescent substance use: exploring differences between youth in Spain and Arizona.

This study aims to comparatively examine drug use in Arizona and Spain, in order to know if similarities and differences in drug use patterns justify the administration in Spain of U.S. prevention intervention programs.

Immigrant advantage? Substance use among Latin American immigrant and native-born youth in Spain.

This article reports the results of a descriptive study conducted with middle school and high school age youth residing in northwestern Spain. The main outcome of the study is to advance knowledge about the drug use attitudes and behaviors of immigrants versus native youth in a social context where Latin American immigrants share a common language and a set of core cultural norms with the host society. The research was conducted by a bi-national Spain-US research team as a preliminary study leading to the development of joint culturally appropriate prevention interventions for youth in the northern region of Galicia, Spain.

Effects produced by Royal Jelly on haematopoiesis: relation with host resistance against Ehrlich ascites tumour challenge.

Royal jelly (RJ) was shown to exhibit immunomodulatory properties, although its biological activity is still unclear. In order to elucidate the mechanism whereby RJ activates the immunological system, we examined the role of this substance on the haematopoietic response of Ehrlich ascites tumour (EAT)-bearing mice. Our results demonstrated that RJ prevented the myelosupression induced by the temporal evolution of the tumour and abrogated the splenic haematopoiesis observed in EAT-bearing mice.

Values and antisocial behavior among Spanish adolescents.

A number of studies have indicated that delinquent adolescents have characteristic value systems. However, most of these studies have adopted a "known-groups" design--that is, they have compared institutionalized delinquents and non-institutionalized adolescents, assuming those adolescents to be non-delinquent. Designs of this type do not distinguish effectively between the statistical effects of delinquency and of institutionalization.

Bone mineral density in asthmatic patients treated with inhaled corticosteroids: a case-control study.

Recent studies suggest that inhaled corticosteroids can adversely affect bone metabolism. The objective of this study was to evaluate the importance of these adverse effects in a case-control study. Bone mineral density (BMD) was measured in 48 asthmatic adults (15 males and 33 females) treated with inhaled steroids (beclomethasone or budesonide) and in 48 gender and age-matched healthy subjects at baseline and at 2 yrs.

Corticosteroid-induced bone loss. Prevention and management.

Osteoporosis is one of the most serious adverse effects experienced by patients receiving long term corticosteroid therapy. Bone loss occurs soon after corticosteroid therapy is initiated and results from a complex mechanism involving osteoblastic suppression and increased bone resorption. There are a number of factors that may increase the risk of corticosteroid-induced osteoporosis [smoking, excessive alcohol (ethanol) consumption, amenorrhoea, relative immobilisation, chronic obstructive pulmonary disease, inflammatory bowel disease, hypogonadism in men, organ transplantation].