Publications by authors named "Luella D Scholtes"

The U(L)17 protein (pU(L)17) of herpes simplex virus 1 (HSV-1) likely associates with the surfaces of DNA-containing capsids in a heterodimer with pU(L)25. pU(L)17 is also associated with viral light particles that lack capsid proteins, suggesting its presence in the tegument of the HSV-1 virion. To help determine how pU(L)17 becomes incorporated into virions and its functions therein, we identified pU(L)17-interacting proteins by immunoprecipitation with pU(L)17-specific IgY at 16 h postinfection, followed by mass spectrometry.

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Article Synopsis
  • Stage-specific changes to the surface lipophosphoglycan (LPG) of Leishmania are vital for the parasite's attachment and release in sand flies, influencing which fly species can spread different parasite strains.* -
  • The study identifies an expanded family of SCG proteins related to PG galactosylation, suggesting that these proteins are expressed in varied patterns during the parasite's lifecycle.* -
  • The arrangement of SCG genes near telomeres might promote gene conversion, contributing to the evolutionary diversity of PG modifications seen in various L. major strains.*
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  • Chlamydiae, a type of bacteria, invade host cells and create a specialized structure (inclusion) where they replicate, but the exact proteins involved in its trafficking are not fully understood.
  • Researchers used green fluorescent protein (GFP) to track various Rab GTPases, which are crucial for membrane trafficking, and found that certain Rab proteins were recruited to Chlamydia infections while others were not.
  • The association of Rab GTPases with the inclusion suggests a specific interaction crucial for regulating the inclusion’s trafficking and fusion with host cell membranes, even when typical cellular structures are disrupted.
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Lipophosphoglycan (LPG) is an abundant surface molecule that plays key roles in the infectious cycle of Leishmania major. The dominant feature of LPG is a polymer of phosphoglycan (PG) (6Galbeta1,4Manalpha1-PO(4)) repeating units. In L.

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