Impacts of Depressive Symptoms on the Effectiveness of a Theory-Driven Exercise Intervention Among Community-Dwelling (Pre)frail Older Adults.

Objectives: To investigate whether baseline depressive symptoms impacted the effectiveness of an exercise intervention among (pre)frail older adults.

Methods: This is a subanalysis of a stepped-wedge cluster randomized trial implementing an exercise intervention, with an application of the integration of the Health Belief Model, Theory of Planned Behavior, and Health Action Process Approach, among 149 community-dwelling (pre)frail older adults. The intervention effectiveness was examined by baseline depressive symptoms (depressive symptoms ( = 40) and non-depressive symptoms ( = 109).

Fully Flexible Humidity Sensor with Fast Response and High Responsivity Based on rGO/MoS for Human Respiration Monitoring and Nontouch Switches.

Humidity sensors have been widely used to monitor humidity in daily life, agriculture fields, and so on. However, conventional sensors are not suitable for wearable devices because of their large dimensions and rigid substrates. Hence, we report a fast response, highly sensitive, and fully flexible humidity sensor on a PI substrate based on the composite material of reduced graphene oxide (rGO)/MoS, with a response time of 0.

TEFM facilitates uterine corpus endometrial carcinoma progression by activating ROS-NFκB pathway.

Background: Mitochondrial transcription elongation factor (TEFM) is a recently discovered factor involved in mitochondrial DNA replication and transcription. Previous studies have reported that abnormal TEFM expression can disrupt the assembly of mitochondrial respiratory chain and thus mitochondrial function. However, the role of TEFM on Uterine corpus endometrial carcinoma (UCEC) progression remains unclear.

Identification of potential biomarkers and pathways involved in high-altitude pulmonary edema using GC-MS and LC-MS metabolomic methods.

High-altitude pulmonary edema (HAPE) is a life-threatening altitude sickness afflicting certain individuals after rapid ascent to high altitude above 2500 m. In the setting of HAPE, an early diagnosis is critical and currently based on clinical evaluation. The aim of this study was to utilize the metabolomics to identify the altered metabolic patterns and potential biomarkers for HAPE.

Association of plasma BDNF and MMP-9 levels with mild cognitive impairment: a matched case-control study.

The prevalence of Alzheimer's disease (AD) is on the rise globally, and everyone who develops AD eventually experiences mild cognitive impairment (MCI) first. Timely intervention at an early stage of the disease may mitigate disease progression. Recent studies indicate that BDNF and MMP-9 play a significant role in the pathogenesis of AD.

Estimation of Spacecraft Angular Velocity Based on the Optical Flow of Star Images Using an Optimized Kalman Filter.

Biomimetic vision is a promising method for efficient navigation and perception, showing great potential in modern navigation systems. Optical flow information, which comes from changes in an image on an organism's retina as it moves relative to objects, is crucial in this process. Similarly, the star sensor is a critical component to obtain the optical flow for attitude measurement using sequences of star images.

X-ray-Triggered Activation of Polyprodrugs for Synergistic Radiochemotherapy.

X-ray-induced photodynamic therapy (XPDT) can penetrate deeply into the tumor tissues to overcome the disadvantage of conventional PDT. However, the therapeutic efficacy of XPDT in cancer therapy is still restricted due to the insufficient reactive oxygen species (ROS) generation at a relatively low irradiation dosage. Herein, we present the tumor pH and ROS-responsive polyprodrug micelles to load the X-ray photosensitizer verteporfin (VP) as an ROS production enhancer.

Root-associated microbial diversity and metabolomics in maize resistance to stalk rot.

As one of the three major food crops in the world, maize plays a significant role in alleviating the food crisis. Maize stalk rot can reduce maize yield and mechanical harvesting efficiency. In addition, mycotoxins such as Deoxynivalenol (DON) and Zearalenone (ZEN) produced by maize stalk rot pathogens can also harm livestock and human health.

Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes.

Backgrounds: Many pregnant women suffer from more than one pregnancy complication. However, whether those women experienced a higher risk of adverse birth outcomes is unclear. This study aims to assess the association between the comorbidity of gestational diabetes mellitus (GDM) and hypertension disorders of pregnancy (HDP) and adverse birth outcomes.

Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors.

Iruplinalkib (WX-0593), a selective oral ALK/ROS1 tyrosine kinase inhibitor, was approved in China as first-line therapy for ALK-positive non-small-cell lung cancer (NSCLC) and for the treatment of locally advanced or metastatic ALK-positive NSCLC that has progressed following crizotinib therapy. Pharmacokinetics (PK) data of iruplinalkib have been collected in healthy subjects and patient populations in several studies. We developed a population PK (PopPK) model for describing iruplinalkib plasma concentrations and for evaluating whether dose adjustments are necessary based on demographic factors or disease characteristics.

Evidence of an emerging triple-reassortant H3N3 avian influenza virus in China.

The H3 subtype of avian influenza virus (AIV) stands out as one of the most prevalent subtypes, posing a significant threat to public health. In this study, a novel triple-reassortant H3N3 AIV designated A/chicken/China/16/2023 (H3N3), was isolated from a sick chicken in northern China. The complete genome of the isolate was determined using next-generation sequencing, and the AIV-like particles were confirmed via transmission electron microscopy.

Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion.

Acute ischemic stroke (AIS) triggers immune responses and neuroinflammation, contributing to brain injury. Histone lactylation, a metabolic stress-related histone modification, plays a critical role in various diseases, but its involvement in cerebral ischemia remains unclear. This study utilized a transient middle cerebral artery occlusion/reperfusion (MCAO/R) model and an oxygen-glucose deprivation/reoxygenation (OGD/R) model to investigate the role of microglial histone lactylation in ischemia-reperfusion injury.

[Mechanism of WAVE1 regulation of lipopolysaccharide-induced mitochondrial metabolic abnormalities and inflammatory responses in macrophages].

Objectives: To explore the mechanism by which Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 (WAVE1) regulates lipopolysaccharide (LPS)-induced mitochondrial metabolic abnormalities and inflammatory responses in macrophages.

Methods: Macrophage cell lines with overexpressed WAVE1 (mouse BMDM and human THP1 cells) were prepared. The macrophages were treated with LPS (500 ng/mL) to simulate sepsis-induced inflammatory responses.

Case report: A successful live birth after fertilization and embryo transfer in a patient with endometrial cancer who was treated conservatively.

Objective: To describe a patient conceiving with fertilization and embryo transfer(IVF-ET) after conservative treatment of early stage endometrial cancer.

Patient: A 31-year-old multiparous woman diagnosed with highly-differentiated (G1) endometrial adenocarcinoma (grade IA).

Interventions: After four courses of conservative treatment each followed by hysteroscopic biopsy and endometrial curettage,assisted reproductive technology was performed.

Craniofacial Development Characteristics in Children with Obstructive Sleep Apnea for Establishment and External Validation of the Prediction Model.

Purpose: Aimed to analyze the developmental characteristics of craniofacial structures and soft tissues in children with obstructive sleep apnea (OSA) and to establish and evaluate prediction model.

Methods: It's a retrospective study comprising 747 children aged 2-12 years (337 patients and 410 controls) visited the Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University (July 2017 to March 2024). Lateral head radiographs were obtained to compare the cephalometric measurements.

Self-Poled Bismuth Ferrite Thin Film Micromachined for Piezoelectric Ultrasound Transducers.

Piezoelectric micromachined ultrasound transducers (pMUTs), especially those using lead-free materials, are crucial next-generation microdevices for precise actuation and sensing, driving advancements in medical, industrial, and environmental applications. Bismuth ferrite (BiFeO) is emerging as a promising lead-free piezoelectric material to replace Pb(Zr,Ti)O in pMUTs. Despite its potential, the integration of BiFeO thin films into pMUTs has been hindered by poling issues.

Remote sensing research on plastics in marine and inland water: Development, opportunities and challenge.

The accumulation of plastic waste from various sources into marine and inland water is considered a global problem due to its serious impacts on aquatic ecosystems and human health. In the past decade, remote sensing has played an important role in monitoring of plastic pollution in marine and inland water sources and has achieved a series of research results in this field. In this study, a comprehensive review was conducted on the development, opportunities, and challenges of datasets and methods in Marine and Inland Water Plastics Remote Sensing (MIWPRS) monitoring over the past decade, based on the Web of Science (WOS) core database.

The role of methyltransferase-like 3 (METTL3) in immune response modulation in bivalve (Mytilus coruscus) during bacterial infection.

N-methyladenosine (m6A) modification is a prevalent mRNA modification that regulates diverse biological processes in eukaryotes, including immune responses. While the role of m6A in mammalian immunity has been explored, its involvement in the immune defense of invertebrates, particularly marine bivalves which face constant pathogen challenges, remains largely unknown. Here, we investigated the function of methyltransferase-like 3 (METTL3), a key m6A "writer" enzyme, in the immune response of the marine bivalve Mytilus coruscus against Vibrio alginolyticus infection.

Association of retinal microvascular abnormalities with all-cause and specific-cause mortality among U.S. adults.

Background: Retinal microvascular abnormalities (RMA) reflect cumulative microvascular damage from systemic diseases and aging. However, little is known about the association between RMA and long-term survival outcomes. This study aimed to examine the relationships between RMA and the risk of all-cause and specific-cause mortality among U.

Highly Air-Stable N-Doped Two-Dimensional Violet Phosphorus with Atomically Flat Surfaces.

Few-layer violet phosphorus (VP) shows excellent potential in optoelectronic applications due to its unique in-plane anisotropy and high mobility. However, the poor air stability of VP severely limits its practical applications. This article reports highly air-stable VP obtained by a two-step nitrogen plasma treatment where the nitrogen volume flow rate is controlled to coordinate physical etching and chemical doping.

Photoexcited Hantzsch Ester Anions Enabled C-F Bond Activation and Hydro-difluoroalkylation of Arylethylenes Through Dual-SET Process.

In this study, we reported a new approach to activate the C-F bond of trifluoromethylarenes to achieve the hydro-difluoroalkylation of arylethylenes using photoexcited Hantzsch esters (HEs) anions. A wide range of α,α-difluoroalkanes was synthesized. Late-stage functionalization of drug molecules and synthesis of bioactive molecule bioisostere were also presented.

The role of macroautophagy in substance use disorders.

Macroautophagy, a universal cellular process, sends cellular material to lysosomes for breakdown and is often activated by stressors like hypoxia or drug exposure. It is vital for protein balance, neurotransmitter release, synaptic function, and neuron survival. The role of macroautophagy in substance use disorders is dual.

A Shape-Memory and Durable Transparent Polyacrylate Film Integrated by Soft-Rigid Chains.

Flexible film in display requires multi-functional integration, such as stretchability, flexibility, abrasion resistance, transparency, and shape memory. In this paper, a reasonable design strategy of flexible polyacrylate (PA) film with high transparency, shape memory, excellent abrasion resistance and foldability is presented. The PA films are prepared by free radical polymerization of vinyl-terminated polyurethane (PU) prepolymer as a cross-linking agent and acrylate monomers in ultraviolet (UV) light.

Realizing Strong and Robust Quasi-1D Superconductors via Multiorbital Chains: NaBe as an Example.

Quasi-one-dimensional (Q1D) systems are inherently unfavorable for superconductivity due to electronic instabilities and significant quantum fluctuations. This has led to a half-century-long pursuit of strong and robust Q1D superconductors. Herein, we propose an effective multiorbital chain approach that utilizes the interorbital self-doping to not only suppress the instability but also to position the Fermi level near the band edges.

Reversing Surface Charge for Highly-Active Organic Photovoltaic Catalysts.

Organic photovoltaic materials typically exhibit low charge separation and transfer efficiency and severe exciton/carrier recombination due to high exciton binding energy and short exciton diffusion lengths, limiting the enhancement of photocatalytic hydrogen evolution performance. Here, we introduce a surface charge reversal strategy to regulate charge characters of organic photovoltaic catalyst (OPC). Compared to OPC nanoparticles (NPs) stabilized by anionic surfactant ((-) NPs), NPs stabilized by cationic surfactant ((+) NPs) exhibit a raised Fermi level, larger surface band bending and Schottky barrier, thereby enhancing charge separation and transfer efficiency while suppressing charge carrier recombination.