Optimizing cover crop practices as a sustainable solution for global agroecosystem services.

The practice of cover crops has gained popularity as a strategy to improve agricultural sustainability, but its full potential is often limited by environmental trade-offs. Using meta-analytic and data-driven quantifications of 2302 observations, we optimized cover crop practices and evaluated their benefits for global agroecosystems. Cover crops have historically boosted crop yields, soil carbon storage, and stability, but also stimulated greenhouse gas emissions.

A bioinspired sulfur-Fe-heme nanozyme with selective peroxidase-like activity for enhanced tumor chemotherapy.

Iron-based nanozymes, recognized for their biocompatibility and peroxidase-like activities, hold promise as catalysts in tumor therapy. However, their concurrent catalase-like activity undermines therapeutic efficacy by converting hydrogen peroxide in tumor tissues into oxygen, thus diminishing hydroxyl radical production. Addressing this challenge, this study introduces the hemin-cysteine-Fe (HCFe) nanozyme, which exhibits exclusive peroxidase-like activity.

Relationship among ultrasound features, pus Mycobacterium tuberculosis load, and efficacy of antituberculosis drugs in patients with necrotizing tuberculous lymphadenitis.

For patients with necrotizing cervical tuberculous lymphadenitis (CTL) who have formed abscesses and are unwilling to undergo surgery, early and accurate assessment of drug therapy should be performed to guide subsequent clinical adjustments. This study investigated 22 patients with necrotizing CTL who underwent chemotherapy at our hospital from February 2020 to December 2022. They were diagnosed based on the positive results of pathogen detection methods (acid-fast bacillus smear, mycobacteria culture, Gene X-pert, and next-generation sequencing).

Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.

Objective: In this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.

Methods: On the basis of the TCGA, GEO, and GTEx databases, an AML secondary database was established, and differential expression analysis and WGCNA were carried out to identify genes related to the prognosis of AML patients. Survival analysis was carried out for internal verification of key genes, and GEO data were used for external verification to obtain core genes related to prognosis.

The association between the aggregate index of systemic inflammation and cardiovascular risk in peritoneal dialysis patients.

Background And Aim: The aggregate index of systemic inflammation (AISI), a novel inflammatory biomarker, is associated with various diseases. However, its association with cardiovascular risk in patients treated with peritoneal dialysis (PD) remains unclear. This study aims to explore the relationship between AISI and cardiovascular risk in this high-risk population, providing new insights for risk stratification and guiding clinical decision-making.

Erythrocyte-Based Biomimetic MOFs as a Triple Epigenetic Regulator for Enhancing Anti-Leukemia Immunity.

While therapeutic strategies targeting epigenetic dysregulation hold promise for leukemia, epigenetic drugs face several limitations, including low utilization rates, the emergence of resistance, and off-target effects. The hypoxic microenvironment in leukemia further impairs drug sensitivity. Here, we synthesized an MOF-based erythrocyte biomimetic nanoplatform to enhance immune responses against leukemia by targeting three epigenetic modifications.

[Development and Clinical Application of High-Magnification Electronic Endoscope].

This article introduces a high-magnification electronic endoscope system that utilizes a continuous zoom optical design, enabling high-magnification imaging at the cellular level. By selecting an appropriate initial retrofocus structure, the optimized modulation transfer function (MTF) curve of the zoom objective lens approaches the diffraction limit. Additionally, the tip and operation parts of the system incorporate modular gas-tight sealing and multiple layers of protective structure.

[Comparative Evaluation of Encephalon State Index and Bispectral Index in Monitoring the Depth of Anesthesia during the Surgical Anesthesia Stage].

Objective: Evaluate the performance of the encephalon state index (ESI) in depth of anesthesia monitoring during clinical surgery, compared with the bispectral index (BIS).

Methods: ESI and BIS data were collected from 60 patients in a single-center clinical trial to compare their efficacy in measuring the depth of anesthesia.

Results: Consistency analysis revealed mean differences and standard deviations of －0.

Current state, challenges and future orientations of the applications of lactic acid bacteria exopolysaccharide in foods.

In the quest for a balanced diet and better health, the global shift towards nutrient-dense foods highlights the multiple roles of lactic acid bacteria exopolysaccharides (LAB-EPS) in improving food quality and health. This paper offers a comprehensive survey of LAB-EPS, focusing on their classification, biosynthesis pathways and application in the food industry, from dairy products to bakery products and meat. It highlights the impact of LAB-EPS on the texture and sensory qualities of food.

Prevalence of antiphospholipid antibodies in COVID-19 patients: A meta-analysis.

Objective: In some reports, antiphospholipid antibodies (aPL) prevalence is higher in COVID-19 patients. This study intended to compare aPL prevalence between COVID-19 patients and healthy controls, and differences in aPL types using meta-analysis.

Methods: This work retrieved published literature about association between COVID-19 and aPL from Embase, Web of Science, PubMed, and The Cochrane Library databases.

A novel linear B cell epitope of the porcine circovirus type 3 capsid protein identified by phage display technology.

Porcine circovirus type 3 (PCV3) is endemic in swine worldwide and causes reproductive disorders, dermatitis and nephrotic syndrome, and multi-organ inflammation. PCV3 capsid protein (Cap) can self-assemble into virus-like particles (VLPs), and is an ideal candidate for vaccines and diagnostic reagents.In this study, the recombinant PCV3 Cap protein was successfully expressed in E.

Advances in plant oxygen sensing: endogenous and exogenous mechanisms.

Oxygen is essential for the biochemical processes that sustain life in eukaryotic organisms. Although plants produce oxygen through photosynthesis, they often struggle to survive in low-oxygen environments, such as during flooding or submergence. To endure these conditions, they must reprogram their developmental and metabolic networks, and the adaptation process involves the continuous detection of both exogenous hypoxic signals and endogenous oxygen gradients.

Patterns, delays, and associated factors of help-seeking behaviour for lifetime mood disorders and anxiety disorders: A national representative survey.

Background: Utilisation of health services is low and delayed among individuals with mood mental disorders and anxiety disorders, despite high disease burdens and available effective treatments. This study aims to examine patterns and delays in help-seeking and associated factors among individuals with lifetime disorder of mood disorders and/or anxiety disorders.

Methods: We used data from the China Mental Health Survey (CMHS), a nationally representative multistage clustered-area probability sample study across 31 provinces.

Efficient removal and recovery of phosphate by biochar loaded with ultrafine MgO nanoparticles.

Biochar loaded with MgO is a promising adsorbent for the removal and recovery of phosphate from aqueous solutions. However, its phosphate adsorption capacity is unsatisfactory, especially at low phosphate concentrations. Loading nanoscale MgO onto biochar is an effective strategy.

lafK contributes the regulation of swarming motility of Pseudomonas plecoglossicida and bacterial-host interaction.

Flagella-mediated swarming motility plays a crucial role in facilitating the rapid colonization and dissemination of bacterial within the host. The swarming motility of Pseudomonas plecoglossicida is intricately associated with its lateral flagella, and notably, the lateral flagella system of P. plecoglossicida encompasses a transcriptional regulator known as LafK.

Insights into the source characterization, risk assessment and ozone formation sensitivity of ambient VOCs at an urban site in the Fenwei Plain, China.

The ground-level O concentration has shown a deteriorating trend in the Fenwei Plain of China, which poses a greater challenge for formulating control strategies of O precursor (VOCs). To accurately control VOCs sources and effectively reduce O concentration from a seasonal perspective, online monitoring of 114 VOCs was conducted at Yuncheng Middle School Station from January 1, 2021 to December 31, 2021. The VOCs concentration showed a seasonal variation with the highest in winter and the lowest in summer.

Three-step surface design of spore-displayed keratinase improved acid tolerance and feather degradation.

The global chicken business has grown rapidly, producing millions of tons of feather waste annually. Keratinase is a special enzyme that catalyzes the degradation of keratin and can be applied to the feed industry. In this study, we initially set the tone for the acid-resistant mutation of spore surface-display keratinase cotG-KERQ7 by replacing base-catalytic residues in the active center.

Molecular design strategy for microorganism discrimination based on keto-salicylaldehyde azine derivatives.

The rapid and selective identification of microorganisms is of great significance for clinical therapy applications. To develop high performance probes for microbe determination, we systemically constructed series aggregation-induced emission (AIE) luminogens by modulating the structural planarity, the basicity of functional group, the length of linker moiety and the hydrophobicity based on our previous work. The detail structure-property relationship study based on experimental and theoretical observation revealed that: i) the planar skeleton is essential for probe insertion towards the cell wall via van n der Waals' force.

Metagenomic insights into the rapid recovery mechanisms of prokaryotic community and spread of antibiotic resistance genes after seawater disinfection.

Disinfectants, such as bleaching powder, are widely employed in marine aquaculture worldwide to control the bacterial pathogens and eliminate antibiotic resistance genes (ARGs). Nevertheless, the rapid recovery of prokaryotic community compositions (PCCs) after disinfection may significantly influence the overall efficacy of disinfection. Presently, little is known about the rapid recovery mechanisms of PCCs and its impact on the removal of ARGs in seawater.

Dual-Indicator loaded porous polymer microneedle patches for rapid and colorimetric detection of water-injected meat.

Water-injected meat leads to microbial growth, which affects the health of consumers. A colorimetric porous polymer microneedle patch was designed and prepared using photopolymerization of an acrylate monomer with porogen to be the substrate, and cobalt (II) chloride as color change indicator and tartrazine as the reference. The color of the microneedle patch changed from green to yellow green and to yellow as the increase of moisture concentration.

Effectively saltiness enhanced odorants screening and prediction by database establish, sensory evaluation and deep learning method.

Odor-taste interaction has gained success in enhancing saltiness perception. This work aimed to provide candidate odorants for saltiness enhancement. Volatile compounds and their frequencies in salty foods were systematically analyzed.

Electronic interactions between SnO crystals and porous N-doped carbon nanoflowers accelerate electrochemical reduction of CO to formate.

The electrochemical carbon dioxide reduction reaction (CORR) to formic acid or formate is a highly effective approach for achieving carbon neutrality. However, multiple proton-coupling-electronic processes and the instability of the catalysts caused by surface poisoning greatly limit the overall efficiency of CORR to formate. Here, a facile method was developed to anchor ∼2.