Risk assessment and clinical prediction model of planned transfer to the ICU after hip arthroplasty in elderly individuals.

Background: With the development of hip arthroplasty technology and rapid rehabilitation theory, the number of hip arthroplasties in elderly individuals is gradually increasing, and their satisfaction with surgery is also gradually improving. However, for elderly individuals, many basic diseases, poor nutritional status, the probability of surgery, anaesthesia and postoperative complications cannot be ignored. How to reduce the incidence of postoperative complications, optimize medical examination for elderly patients, and reasonably allocate medical resources.

Effect of Cold Working on the Properties and Microstructure of Cu-3.5 wt% Ti Alloy.

Cu-Ti alloys were strengthened by β'-CuTi metastable precipitation during aging. With the extension of the aging time, the β'-CuTi metastable phase transformed into the equilibrium β-CuTi phase. The Cu-3.

A Novel System for the Quantification of the ADCC Activity of Therapeutic Antibodies.

Novel ADCC effector cells expressing the V-variant or F-variant of FcRIIIa (CD16a) and firefly luciferase under the control of a chimeric promoter incorporating recognition sequences for the principal transcription factors involved in FcRIIIa signal transduction, together with novel target cells overexpressing a constant high level of the specific antigen recognized by rituximab, trastuzumab, cetuximab, infliximab, adalimumab, or etanercept, confer improved sensitivity, specificity, and dynamic range in an ADCC assay relative to effector cells expressing a NFAT-regulated reporter gene and wild-type target cells. The effector cells also contain a normalization gene rendering ADCC assays independent of cell number or serum matrix effects. The novel effector and target cells in a frozen thaw-and-use format exhibit low vial-to-vial and lot-to-lot variation in their performance characteristics reflected by CVs of 10% or less.

Mitochondria associate with P-bodies and modulate microRNA-mediated RNA interference.

P-bodies are cytoplasmic granules that are linked to mRNA decay, mRNA storage, and RNA interference (RNAi). They are known to interact with stress granules in stressed cells, and with late endosomes. Here, we report that P-bodies also interact with mitochondria, as previously described for P-body-related granules in germ cells.