Publications by authors named "Ludwin A"

Gestational diabetes mellitus (GDM) occurs in approximately 9% of pregnancies, and proper glycemic control is of utmost importance in the prevention of GDM-associated obstetric complications. Flash glucose monitoring (FGM), a subtype of continuous glucose monitoring (CGM), offers intermittent blood glucose scanning and is considered a propitious alternative to the standard method of self-monitoring of blood glucose (SMBG). The aim of this review was to systematically assess the efficacy and acceptability of FGM in in pregnancies complicated by GDM.

View Article and Find Full Text PDF
Article Synopsis
  • - Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP) is a rare tumor that doesn't fit the typical definitions of benign (leiomyoma) or malignant (leiomyosarcoma), and its symptoms can mimic benign conditions without specific markers for diagnosis.
  • - A case study of a 42-year-old woman illustrates the diagnosis and treatment of STUMP; she initially underwent surgery for what was thought to be a benign leiomyoma, and post-surgery, histopathology revealed it was actually a STUMP, yet she is recurrence-free after 9 months.
  • - Managing STUMP requires a tailored strategy that involves various medical fields, taking into account the patient's future fertility plans, as well as addressing the
View Article and Find Full Text PDF
Article Synopsis
  • Endometrial cancer is a common cancer in women's reproductive health, with rising incidence and mortality, making early diagnosis essential for effective treatment.
  • This paper reviews existing literature on the impact of nutritional status, particularly micronutrients and macronutrients, on endometrial cancer patients, focusing on metallomic studies.
  • While some nutrients like calcium might reduce risk, and deficiencies in phosphorus, selenium, and zinc may offer protection, excess iron, copper, and cadmium increase risk, pointing to a complex relationship that requires more research to fully understand potential nutritional interventions.
View Article and Find Full Text PDF

In this study, we aimed to assess and compare the prevalence of septate uterus using the diagnostic criteria of the ESHRE-ESGE, ASRM 2016, ASRM 2021, and CUME classifications. This prospective observational study included 977 women of reproductive age. Each participant underwent a transvaginal ultrasound, and a 3D volume of the uterus was obtained for further analysis.

View Article and Find Full Text PDF

Hemolytic disease of the fetus and newborn (HDFN) is caused by maternal antibodies attacking fetal blood cell antigens. Despite routine antenatal anti-D prophylaxis, intrauterine transfusions (IUTs) are still needed in some HDFN cases. We conducted a retrospective cohort study on newborns with HDFN born in the 1st Department of Obstetrics and Gynecology of the Medical University of Warsaw.

View Article and Find Full Text PDF
Article Synopsis
  • - This text discusses a rare case of transient abnormal myelopoiesis (TAM), a hematologic disorder usually seen in babies with trisomy 21, identified in a newborn with a normal karyotype.
  • - The case involved a pregnant woman who presented with reduced fetal movements and was found to have indicators of fetal distress, prompting an emergency cesarean section that resulted in the delivery of a female newborn with notable blood abnormalities.
  • - The study emphasizes the importance for obstetricians to recognize signs like elevated middle cerebral artery peak systolic velocity and hepatosplenomegaly, which could indicate fetal blood disorders, and distinguishes these from other conditions like infections or isoimmunization.
View Article and Find Full Text PDF

: One of the rare causes of cholestasis may be hemolytic disease of the fetus and newborn (HDFN). : We retrospectively analyzed 88 medical records of HDFN newborns with cholestasis and 186 records of children with HDFN without cholestasis and conducted an observational, case-control, retrospective study. : Factors influencing the risk of cholestasis were lower gestational age at birth (36.

View Article and Find Full Text PDF
Article Synopsis
  • - Lung transplantation can be a viable treatment for cystic fibrosis (CF) patients with severe lung issues, and while pregnancy is possible for these patients, it involves significant challenges and requires a coordinated healthcare approach.
  • - A case study details a 22-year-old woman who became pregnant 2.5 years post-lung transplant, where she was closely monitored and had her medications adjusted to avoid complications.
  • - Successful delivery of a healthy baby was achieved through a planned caesarean section, demonstrating that with proper care and patient cooperation, pregnancy after lung transplantation can result in positive outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • * A case involving twins showed direct bilirubin levels of 32.2 mg/dL and 50.2 mg/dL, but they exhibited no major signs of liver dysfunction.
  • * The condition was linked to Rhesus factor immunization in the mother, resulting in fetal anemia and necessitating blood transfusions, making this the first documented case of such high bilirubin levels specifically from HDFN.
View Article and Find Full Text PDF

Twin reversed arterial perfusion sequence (TRAP) is a rare complication of monochorionic twins (MC). This study aimed to describe and compare the short- and long-term outcomes of MC pregnancies with the TRAP sequence treated with two different techniques: interstitial fetal laser (IFL) ( = 22) versus endoscopic cord occlusion (CO) ( = 24). The study population included 46 MC pregnancies with TRAP.

View Article and Find Full Text PDF

Introduction: The purpose of our study was tomeasure the level of leptin and biologically active leptin (bioLEP) in children with type 1 diabetes, depending on the duration of diabetes and its degree of metabolic control.

Methods: The study included 94 children (58 boys and 36 girls). In a group of children with diabetes, 40 patients were newly diagnosed with type 1 diabetes, 40 children who have diabetes for more than a year (20 with good metabolic control and 20 with poor metabolic control).

View Article and Find Full Text PDF

Objective: This study aimed to assess the utility of circulating miR-125b-5p, miR-199a-3p, miR-451a, and miR-3613-5p as biomarkers of endometriosis.

Study Design: Patients with stage III or IV of endometriosis according to the revised American Society of Reproductive Medicine (rASRM) staging classification, as well as control women, were recruited. We created a prospective study conducted on a group of 48 patients (n = 25 controls, n = 24 endometriosis) who had laparoscopic surgery.

View Article and Find Full Text PDF

Endometrial cancer remains a common cancer affecting the female reproductive system. There is still a need for more efficient ways of determining the degree of malignancy and optimizing treatment. WNT and mTOR are components of signaling pathways within tumor cells, and dysfunction of either protein is associated with the pathogenesis of neoplasms.

View Article and Find Full Text PDF

The high efficacy of modern assisted reproductive technology (ART) and increase in the number of noninfertile patients who are using ART for family building in the United States call into question the relevance of the standard, one-size-fits-all infertility evaluation. Here, we explore whether all patients presenting for ART need uterine cavity and tubal assessment and what tests are most appropriate, efficient, and cost-effective in current times.

View Article and Find Full Text PDF

(1) Endometrial cancer is one of the most common cancers affecting women, with a growing incidence. To better understand the different behaviors associated with endometrial cancer, it is necessary to understand the changes that occur at a molecular level. CD133 is one of the factors that regulate tumor progression, which is primarily known as the transmembrane glycoprotein associated with tumor progression or cancer stem cells.

View Article and Find Full Text PDF

Uterine fibroids (UFs) are very common benign tumors of the female reproductive tract. According to recent reports, magnetic resonance-guided high-intensity ultrasound (MR-HIFU) appears to be a well-tolerated and efficient treatment option for UFs. However, MR-HIFU still presents several limitations.

View Article and Find Full Text PDF

Study Question: What recommendations can be provided to improve terminology for normal and ectopic pregnancy description on ultrasound?

Summary Answer: The present ESHRE document provides 17 consensus recommendations on how to describe normally sited and different types of ectopic pregnancies on ultrasound.

What Is Known Already: Current diagnostic criteria stipulate that each type of ectopic pregnancy can be defined by clear anatomical landmarks which facilitates reaching a correct diagnosis. However, a clear definition of normally sited pregnancies and a comprehensive classification of ectopic pregnancies are still lacking.

View Article and Find Full Text PDF