Publications by authors named "Ludovico Di Gioia"
Aims: To compare the efficacy and safety of different hybrid closed loop (HCL) systems in people with diabetes through a network meta-analysis.
Methods: We searched MEDLINE, EMBASE, CENTRAL and PubMed for randomised clinical trials (RCTs) enrolling children, adolescents and/or adults with type 1 or type 2 diabetes, evaluating Minimed 670G, Minimed 780G, Control-IQ, CamAPS Fx, DBLG-1, DBLHU, and Omnipod 5 HCL systems against other types of insulin therapy, and reporting time in target range (TIR) as outcome.
Results: A total of 28 RCTs, all enrolling people with type 1 diabetes, were included.
Article Synopsis
- Carney complex (CNC) is a rare disease caused by changes in the PRKAR1A gene, leading to skin changes and various tumors.
- A 41-year-old woman with a complicated medical history faced challenges when doctors tried to find out what was wrong with her, which included multiple tumors and strokes.
- Genetic testing finally confirmed she had CNC, showing how important teamwork among doctors is for diagnosing and treating rare health issues.
Background: Innovative GLP-1 receptor agonist (GLP-1RA)-based treatment strategies-such as tirzepatide, GLP-1RA plus basal insulin fixed-ratio combinations [FRC], GLP-1RA plus sodium glucose cotransporter-2 inhibitors [SGLT-2i] combinations, and high-dose GLP-1RA-have been listed among the most efficacious options for type 2 diabetes management. However, differences in their glucometabolic effects have not been assessed in dedicated head-to-head trials. In the absence of such trials, we aimed to provide a useful comparison among these treatment strategies to guide clinical practice.
View Article and Find Full Text PDFType 2 diabetes (T2D) and Alzheimer's diseases (AD) represent major health issues that have reached alarming levels in the last decades. Although growing evidence demonstrates that AD is a significant comorbidity of T2D, and there is a ~1.4-2-fold increase in the risk of developing AD among T2D patients, the involvement of possible common triggers in the pathogenesis of these two diseases remains largely unknown.
View Article and Find Full Text PDFObesity with its associated complications represents a social, economic and health problem of utmost importance worldwide. Specifically, obese patients carry a significantly higher risk of developing cardiovascular disease compared to nonobese individuals. Multiple molecular mechanisms contribute to the impaired biological activity of the distinct adipose tissue depots in obesity, including secretion of proinflammatory mediators and reactive oxygen species, ultimately leading to an unfavorable impact on the cardiovascular system.
View Article and Find Full Text PDFArticle Synopsis
- Flash glucose monitoring (FGM) is a sensor-based technology that measures glucose levels in patients with type 1 and type 2 diabetes, and a systematic review assessed its efficacy and safety in over 2100 patients.
- The review found FGM use led to a significant reduction in HbA1c levels and decreased time spent below 70 mg/dL, with positive patient-reported outcomes and no serious adverse events related to the device.
- When compared to traditional self-monitoring blood glucose (SMBG), FGM required fewer daily SMBG measurements and had a lower discontinuation risk, although the studies reviewed had varying designs and limited follow-up.