Publications by authors named "Ludovica Timperi"
Article Synopsis
- Human adipose tissue (dWAT) plays a critical role in the regulation of hair follicle (HF) physiology, particularly during the anagen to catagen transition, affecting both the size and number of peripheral adipocytes.
- Research findings indicate that dWAT enhances hair growth and pigmentation through the secretion of hepatocyte growth factor (HGF), which stimulates hair matrix keratinocyte proliferation and activates Wnt/β-catenin signaling pathways.
- The results highlight dWAT and HGF as potential therapeutic targets for addressing hair growth and pigmentation disorders.
Leptin (Lep) stimulates keratinocytes to proliferate, intervenes in the wound healing and participates to hair follicle morphogenesis and cycle. While it is secreted by skin structures including epidermis and hair follicles, intradermal adipose tissue also seems to have a role in Lep secretion and accordingly in the control of hair follicle growth in mice and humans. Lep was investigated in the skin of humans and laboratory animals but there are not data regarding bovine species.
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