Stress and the City: Mental Health in Urbanized vs. Rural Areas in Salzburg, Austria.

Background: Living in the city is associated with a higher risk of suffering from stress, anxiety, and depression. Due to an increase of migration to the city, the association between mental health and city life is highly relevant to society.

Methods: We analyzed data of 9573 participants (Ø 55.

Afamin predicts the prevalence and incidence of nonalcoholic fatty liver disease.

Objectives: In the general population, increased afamin concentrations are associated with the prevalence and incidence of metabolic syndrome as well as type 2 diabetes. Although metabolic syndrome is commonly associated with nonalcoholic fatty liver disease (NAFLD), there exist no information on afamin and NAFLD.

Methods: Afamin concentrations were cross-sectionally measured in 146 Austrian patients with NAFLD, in 45 patients without NAFLD, and in 292 age- and sex-matched healthy controls.

Efficacy and tolerability of alirocumab in Austrian clinical practice - results of the non-interventional PEARL-AT study.

Objective: Proprotein convertase subtilisin/kexin type 9 inhibition can be an effective treatment in patients with primary hypercholesterolemia, particularly in cases with concomitant coronary heart disease, peripheral artery occlusive disease or cerebrovascular occlusive disease for secondary prevention after an acute atherosclerotic ischemic event. The primary objective of the PEARL-AT study was to assess effectiveness and safety of alirocumab in a real-world setting in Austria.

Methods: Non-interventional, prospective study conducted across Austria between September 2016 and July 2018.

Higher spermidine intake is linked to lower mortality: a prospective population-based study.

Background: Spermidine administration is linked to increased survival in several animal models.

Objective: The aim of this study was to test the potential association between spermidine content in diet and mortality in humans.

Design: This prospective community-based cohort study included 829 participants aged 45-84 y, 49.

Circulating Wnt inhibitory factor 1 levels are associated with development of cardiovascular disease.

Background And Aims: Wnt signaling is involved in atherosclerotic plaque formation directly and indirectly by modulating cardiovascular risk factors. We investigated whether circulating concentrations of Wnt inhibitors are associated with cardiovascular events in subjects with intermediate cardiovascular risk.

Methods: 904 non-diabetic subjects participating in the SAPHIR study were assessed.

Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals.

Objective: The human vitamin E-binding glycoprotein afamin is primarily expressed in the liver and has been associated with prevalent and incident metabolic syndrome. These data were in line with observations in transgenic mice. We thus investigated whether afamin concentrations are associated with prediabetes, type 2 diabetes, and insulin resistance (IR).

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.

High lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) kringle IV repeat isoforms. We aimed to identify genetic loci associated with Lp(a) concentrations using data from five genome-wide association studies (n = 13,781).

Association Between Vascular Cell Adhesion Molecule 1 and Atrial Fibrillation.

Importance: Accumulating evidence links inflammation and atrial fibrillation (AF).

Objective: To assess whether markers of systemic and atrial inflammation are associated with incident AF in the general population.

Design, Setting, And Participants: The Bruneck Study is a prospective, population-based cohort study with a 20-year follow-up (n = 909).

Specific circulating phospholipids, acylcarnitines, amino acids and biogenic amines are aerobic exercise markers.

Objectives: Regular aerobic exercise provides beneficial effects on human health and reduces all-cause mortality. Aerobic exercise has profound metabolic effects, and specific metabolites may reflect physiological changes. We aimed to identify endogenous metabolites that distinguish the trained from the untrained state to increase the spectrum of analytes amenable for hypothesis testing and to expand understanding of putative beneficial pathways.

A genome-wide association meta-analysis on apolipoprotein A-IV concentrations.

Apolipoprotein A-IV (apoA-IV) is a major component of HDL and chylomicron particles and is involved in reverse cholesterol transport. It is an early marker of impaired renal function. We aimed to identify genetic loci associated with apoA-IV concentrations and to investigate relationships with known susceptibility loci for kidney function and lipids.

Influence of DNA extraction methods on relative telomere length measurements and its impact on epidemiological studies.

Measurement of telomere length is widely used in epidemiologic studies. Insufficient standardization of the measurements processes has, however, complicated the comparison of results between studies. We aimed to investigate whether DNA extraction methods have an influence on measured values of relative telomere length (RTL) and whether this has consequences for epidemiological studies.