Publications by authors named "Ludmila M Flores"
Article Synopsis
- The study aimed to identify a specific microRNA (miRNA) pattern that could serve as a biomarker for head and neck squamous cell carcinoma (HNSCC), focusing on tongue cancer due to the disease's complexity and varied research methods.
- Researchers collected plasma samples, tumor, and benign tissues from patients undergoing surgery, analyzing both circulating and tissue-specific miRNAs to determine differences in expression levels.
- The results showed a distinct profile of miRNAs that were differently expressed in tumor tissue compared to benign tissue, with circulating exosomes being a more reliable source for assessing these tumor-related miRNAs, suggesting potential for future biomarker development.
BM mesenchymal stromal cells (BM-MSCs) support multiple myeloma (MM) cell growth, but little is known about the putative mechanisms by which the BM microenvironment plays an oncogenic role in this disease. Cell-cell communication is mediated by exosomes. In this study, we showed that MM BM-MSCs release exosomes that are transferred to MM cells, thereby resulting in modulation of tumor growth in vivo.
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- Interactions between multiple myeloma (MM) cells and the bone marrow (BM) microenvironment are essential for MM progression and drug resistance, focusing on the role of P-selectin glycoprotein ligand-1 (PSGL-1).
- PSGL-1, found in high levels on MM cells, plays a key role in their adhesion and homing to BM cells, influencing cell proliferation and resistance to treatments.
- The study shows that using a pan-selectin inhibitor (GMI-1070) disrupts these interactions, making MM cells more sensitive to the drug bortezomib, indicating a potential therapeutic pathway.
Article Synopsis
- Researchers are investigating eIF4E as a biomarker and treatment target in breast cancer due to its role in promoting the production of growth-related mRNAs and its overexpression in cancer.
- The study found that ribavirin, an eIF4E inhibitor, effectively reduced breast cancer cell growth and changed the expression of mRNAs linked to eIF4E, though responses varied among different cell lines.
- High eIF4E mRNA levels in tumors could indicate poor outcomes, particularly in luminal B breast cancer, suggesting that targeting eIF4E might be beneficial for certain subtypes of breast cancer.
Article Synopsis
- * Reducing the levels of specific integrins (alpha6beta4, alpha3beta1) and the tetraspanin protein CD151 can reverse this resistance, making cells more susceptible to these treatments.
- * Inhibition of components related to this adhesion process—like laminin-5, integrins, CD151, and focal adhesion kinase (FAK)—can significantly enhance the effectiveness of anti-ErbB2 therapies in tackling drug resistance in ErbB2+ breast cancers.
Article Synopsis
- The study focused on SNP distribution in genes related to inflammation in tuberculosis patients and healthy individuals in Mexico, highlighting the significance of MCP-1 genotypes.
- Carriers of the MCP-1 genotypes AG and GG had significantly higher chances of developing tuberculosis compared to those with genotype AA, with homozygous GG showing the highest MCP-1 levels.
- The research further demonstrated that high MCP-1 levels inhibit IL-12p40 production in response to M. tuberculosis, suggesting a link between MCP-1 genotype and the progression of tuberculosis, a trend also observed in a Korean population.