Consequent stages of developing a multi-compartmental mechanistic model for chronically inhaled nanoparticles pulmonary retention.

The paper retraces the development of a mechanistic multicompartmental system model describing particle retention in lungs under chronic inhalation exposures. This model was first developed and experimentally tested for various conditions of exposure to polydisperse dusts of SiO or TiO. Later on it was successfully used as a basis for analyzing patterns in the retention of nanoparticles having different chemical compositions (FeO, SiO, NiO).