Photobiomodulation of local alterations induced by BthTX-I, a phospholipase A myotoxin from Bothrops jararacussu snake venom: In vivo and in vitro evaluation.

This report describes the effect of photobiomodulation (PBM) on edema formation, leukocyte influx, prostaglandin E (PGE) biosynthesis and cytotoxicity caused by bothropstoxin-I (BthTX-I), a phospholipase A (PLA) homologue isolated from Bothrops jararacussu snake venom. Swiss mice or C2C12 cells were irradiated with low-level laser (LLL) at 685nm wavelength, an energy density of 4.6J/cm and an irradiation time of 13s.

Effect of low-level laser therapy in the myonecrosis induced by Bothrops jararacussu snake venom.

Objective: The aim of this work was to investigate the capacity of low-level laser therapy (LLLT) alone or in combination with antivenom (AV) to reduce myonecrosis induced by Bothrops jararacussu snake venom.

Background Data: Myonecrosis is the most pronounced local effect caused by B. jararacussu venom.