Publications by authors named "Ludivine Rotard"
The potential pathogenic role of disturbed Ca2+ homeostasis in Duchenne muscular dystrophy (DMD) remains a complex, unsettled issue. We used muscle fibers isolated from 3-mo-old DMDmdx rats to further investigate the case. Most DMDmdx fibers exhibited no sign of trophic or morphology distinction as compared with WT fibers and mitochondria and t-tubule membrane networks also showed no stringent discrepancy.
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- Rippling muscle disease (RMD) is marked by muscle stiffness and rippling, often linked to hereditary gene variations or autoimmune conditions like myasthenia gravis and thymoma.
- A recent case study identified MURC/Cavin-4 autoantibodies in a patient with paraneoplastic iRMD who was negative for AchR antibodies and had thymoma, suggesting a specific autoimmune response.
- Tumor removal and immunotherapy significantly reduced MURC/Cavin-4 autoantibody levels, leading to the disappearance of muscle symptoms and patient remission, indicating these autoantibodies may drive the disease in thymoma cases.