Publications by authors named "Lucy-May Young"

DILI is a major cause of attrition in drug development with over 1000 FDA-approved drugs known to potentially cause DILI in humans. Unfortunately, DILI is often not detected until drugs have reached clinical stages, risking patients' safety and leading to substantial losses for the pharma industry. Taking into account that standard 2D models have limitations in detecting DILI it is essential to develop in vitro models that are more predictive to improve data translatability.

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Article Synopsis
  • * Researchers developed an in vitro microphysiological system (MPS) to model liver fibrosis and advanced NASH features using primary human liver cells under various conditions.
  • * The model's characteristics closely resembled those of actual patient samples, and treatments like Obeticholic acid and Elafibranor, along with dietary changes, significantly reduced inflammation and fibrosis, showing its effectiveness in studying advanced NASH.
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