Publications by authors named "Lucy Y Gao"
Front Immunol
October 2024
Article Synopsis
- CD44 is a glycoprotein linked to kidney inflammation and fibrosis, specifically studied in a mouse model for lupus nephritis (LN) and in human patients with active LN.
- The research showed that CD44 was absent in healthy kidneys but expressed in kidney cells of LN patients, and treatment with anti-CD44 antibodies improved kidney health in mice by reducing immune cell infiltration and fibrosis markers.
- Serum CD44 levels increased before clinical symptoms of renal flare in patients, effectively distinguishing those with active LN from healthy individuals and other kidney-related conditions.
