Age-Related Changes in Vancomycin Protein Binding: Is It Time to Take It Seriously?

Background: Vancomycin (VAN) protein binding in plasma is influenced by illness and age; hence, doses titrated according to total concentrations are fraught. In this study, model-estimated free VAN concentrations (EFVC) were compared with assumed free VAN concentrations (AFVC) in neonates, children, and adults in the intensive care unit and those on dialysis.

Methods: Patient cohorts were identified from the hospital database.

Continuous infusion of vancomycin improved therapeutic levels in term and preterm infants.

Background: Growing evidence suggests that continuous infusion of vancomycin (CIV) is superior to intermittent infusion of vancomycin (IIV) in neonates. This quality improvement (QI) project aimed to transition from IIV to CIV with earlier and improved attainment of therapeutic vancomycin levels.

Methods: The Model for Improvement framework with Plan Do Study Act cycles was used.