Publications by authors named "Lucy S Cheng"
Article Synopsis
- In 2015, T-VEC, an oncolytic virus derived from HSV-1, was the first of its kind approved for cancer treatment, particularly for melanoma, but its effectiveness is limited and mechanisms of HSV-1 replication in cancer cells are not well understood.
- Researchers studied how BACH1, an interferon-stimulated gene, controls HSV-1 replication and discovered that its deficiency enhances the virus's ability to induce cancer cell death.
- The findings suggest that targeting BACH1 could improve the effectiveness of HSV-1 in cancer therapies, evidenced by using hemin to boost antitumor activity and T cell infiltration in tumors.
Article Synopsis
- The study investigates the role of the transcription factor SIX1 in the tumor microenvironment (TME) and its effect on tumor growth and immune cell infiltration.
- Researchers found that higher levels of SIX1 in tumor tissues were linked to lower immune cell presence and worse survival rates for cancer patients.
- Deleting SIX1 in cancer cells decreased tumor growth by boosting immune responses, highlighting its potential as a target for cancer immunotherapy through its influence on collagen production and immune activation.