J Cosmet Dermatol
November 2022
Background: Melasma is an acquired melanogenesis dysfunction resulting in chronic hyperpigmentation commonly affecting the face and other frequently sun-exposed areas of the body. Melasma typically presents in women of reproductive age and can significantly impact self-esteem, negatively affecting one's quality of life. In the United States, melasma is often treated with application of topical agents that interfere with melanin synthesis, lasers, or chemical peels; however, in some East Asian countries, oral tranexamic acid (TXA) is widely administered to alleviate hyperpigmentation during and after childbirth.
View Article and Find Full Text PDFAge is a risk factor for numerous diseases, including neurodegenerative diseases, cancers, and diabetes. Loss of protein homeostasis is a central hallmark of aging. Activation of the endoplasmic reticulum unfolded protein response (UPR ) includes changes in protein translation and membrane lipid synthesis.
View Article and Find Full Text PDFThe unfolded protein response in the endoplasmic reticulum (UPR) is involved in a number of metabolic diseases. Here, we characterize UPR-induced metabolic changes in mouse livers in vivo through metabolic labeling and mass spectrometric analysis of lipid and proteome-wide fluxes. We induced UPR by tunicamycin administration and measured synthesis rates of proteins, fatty acids and cholesterol, as well as RNA-seq.
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