Publications by authors named "Lucy M Yanckello"
J Cell Immunol
January 2021
Article Synopsis
- Alzheimer’s disease (AD) is the most prevalent form of dementia, characterized by β-amyloid plaques and tau tangles, with brain metabolic deficits being a key predictor of disease severity.
- A metabolomics analysis of brain tissue from 158 older adults revealed distinct biochemical profiles associated with AD based on factors like apolipoprotein E genotype and disease stage, indicating metabolic processes vary significantly between healthy and AD-affected brains.
- The study found that different metabolites, particularly in gray and white matter, are critical in distinguishing AD severity and could inform targeted lifestyle and dietary strategies to reduce AD risk in early disease stages.
