Publications by authors named "Lucy Jiang"
Article Synopsis
- cGAMP is a newly discovered cyclic dinucleotide in bacteria with unknown signaling activators, and its signaling pathways seem limited due to specific synthases.
- Cyclic AMP (cAMP) has been found to activate the GacB enzyme in Myxococcus xanthus, while cyclic di-GMP directly inhibits GacB, indicating interaction between different cyclic dinucleotide pathways.
- The enzyme PmxA acts as a specific phosphodiesterase for cGAMP and enhances resistance to osmotic stress in M. xanthus; an amino acid change in PmxA suggests potential new phosphodiesterases that might exist in various bacterial species.
Cystic fibrosis (CF) patients often acquire chronic respiratory tract infections due to Pseudomonas aeruginosa and Burkholderia cepacia complex (Bcc) species. In the CF lung, these bacteria grow as multicellular aggregates termed biofilms. Biofilms demonstrate increased (adaptive) resistance to conventional antibiotics, and there are currently no available biofilm-specific therapies.
View Article and Find Full Text PDF