Using Triazabutadienes as a Protected Source of Diazonium Cations to Facilitate Electrografting to a Variety of Conductive Surfaces.

Aryl diazonium electrografting is a versatile methodology for the functionalization of electrode surfaces, yet its usage has been hampered by both the short lifespan of aryl diazonium cations in aqueous solution and the harsh conditions required to generate them . This can make accessing complicated aryl diazonium cations and derivatized surfaces thereof difficult. The usage of triazabutadienes has the potential to address many of these issues as triazabutadienes are stable enough to endure multiple-step chemical syntheses and can persist for several hours in aqueous solution, yet upon UV exposure rapidly release aryl diazonium cations under mild conditions (i.

Evaluating baculovirus as a vector for human prostate cancer gene therapy.

Gene therapy represents an attractive strategy for the non-invasive treatment of prostate cancer, where current clinical interventions show limited efficacy. Here, we evaluate the use of the insect virus, baculovirus (BV), as a novel vector for human prostate cancer gene therapy. Since prostate tumours represent a heterogeneous environment, a therapeutic approach that achieves long-term regression must be capable of targeting multiple transformed cell populations.