Publications by authors named "Lucy Hanington"

To delineate further the clinical phenotype of Lamb-Shaffer Syndrome (LSS) 16 unpublished patients with heterozygous variation in SOX5 were identified either through the UK Decipher database or the study team was contacted by clinicians directly. Clinical phenotyping tables were completed for each patient by their responsible clinical geneticist. Photos and clinical features were compared to assess key phenotypes and genotype-phenotype correlation.

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Article Synopsis
  • Many adults with life-threatening conditions struggle to balance their health issues while parenting, often feeling uncertain about discussing their diagnosis with their children.
  • Children are generally aware of their parents' health struggles and desire honest conversations regarding the situation, which can impact their emotional wellbeing.
  • The review highlights the role of healthcare professionals in guiding parents on effective communication, while also addressing the lack of evidence-based guidelines and outlining preferences for communication from both children and parents.
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Article Synopsis
  • Communicating a life-threatening diagnosis to children and their families is a complex challenge for healthcare professionals that requires careful consideration of the child's developmental understanding of illness and death.
  • Evidence-based guidelines are needed across all healthcare settings to improve this communication process, especially in areas with high child mortality rates.
  • The Review highlights the impact of effective communication on emotional and social outcomes for children, adherence to treatment, and overall family dynamics, while also discussing common barriers and offering expert-driven principles for better communication.
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Importance: Paternal depression during the postnatal period has been associated with adverse child outcomes. Family environment has been reported as a pathway for risk transmission from fathers to children. The influence of paternal depression during the postnatal period on offspring depression remains to be clarified.

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Objective: To explore potential mediating and moderating factors that influence the association between paternal depression in the postnatal period and subsequent child behavioral and emotional problems.

Methods: A population-based cohort (N = 13,822) from the Avon Longitudinal Study of Parents and Children (ALSPAC) was recruited during pregnancy. Paternal and maternal depressive symptoms were assessed with the Edinburgh Postnatal Depression Scale at 8 weeks after the birth of the child.

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Current research supports a link between maternal depression and difficult child temperament. The direction of effect is often assumed to be from parent to child, but few studies have addressed child to parent effects. In a large cohort study, the Avon Longitudinal Study of Parents and Children (ALSPAC) (N=14663), we aimed to further existing knowledge by investigating the relationship between maternal and paternal depressive symptoms and child temperament, and determining the direction of any effects found.

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