Publications by authors named "Lucy Flett"

Article Synopsis
  • Chikungunya virus (CHIKV) is a virus transmitted by mosquitoes that causes severe joint pain and fever, continuing to cause outbreaks globally since 2005.
  • To test potential vaccines and antivirals, researchers compared disease progression and viral loads in different mouse strains, focusing on A129 (which lacks a specific receptor) and C57BL/6.
  • Findings showed that A129 mice experienced more severe disease compared to their parental 129Sv/Ev strain, and 129Sv/Ev mice had higher viral loads than C57BL/6, establishing important models for future research.
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Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing disease in livestock and humans. Whilst initially restricted to the African continent, recent spread to the Arabian Peninsula has highlighted the likelihood of entry into new regions. Due to the absence of a regulatory-approved human vaccine, work is ongoing to develop and assess countermeasures.

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Nipah virus (NiV) is an emerging pathogen that can cause severe respiratory illness and encephalitis in humans. The main reservoir is fruit bats, distributed across a large geographical area that includes Australia, Southeast Asia, and Africa. Incursion into humans is widely reported through exposure of infected pigs, ingestion of contaminated food, or through contact with an infected person.

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