Publications by authors named "Lucy Core"
Background: Impaired auditory verbal working memory is a diagnostic hallmark and integral driver of the clinical phenotype in logopenic variant primary progressive aphasia (lvPPA). However, the physiology of the working memory buffer in this syndrome is poorly characterised. Here we addressed the temporal dynamics of auditory verbal working memory in patients with lvPPA and typical Alzheimer's disease (tAD).
View Article and Find Full Text PDFWorking memory for nonverbal auditory information is essential for everyday functioning but its cognitive organisation is not well understood. Here we addressed this issue in a musician, YA, with absolute pitch (AP, the uncommon ability to categorise and label individual musical pitches without an external reference) who developed posterior cortical atrophy. We assessed YA's AP ability and her working memory for pitch and rhythmic patterns using procedures modelled on a standard test of auditory verbal working memory (digit span), referenced to age-matched, cognitively-normal AP and non-AP possessing musicians.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated both peripheral (basic hearing ability) and central (speech processing ability) hearing in different dementia patients compared to healthy individuals.
- Findings revealed that while central hearing (measured through dichotic listening) was significantly impaired in dementia patients, peripheral hearing (measured with pure-tone audiometry) showed no notable difference from healthy controls.
- The results suggest a critical link between central hearing abilities and cognitive functioning in dementia, emphasizing the need to assess both types of hearing to better understand and address the auditory challenges faced by these patients.
Objectives: On phenotypic and neuroanatomical grounds, music exposure might potentially affect the clinical expression of behavioural variant frontotemporal dementia (bvFTD). However, this has not been clarified.
Methods: 14 consecutive patients with bvFTD fulfilling consensus diagnostic criteria were recruited via a specialist cognitive clinic.
Binary reversals: a diagnostic sign in primary progressive aphasia.
J Neurol Neurosurg Psychiatry
April 2024
Article Synopsis
- Binary reversals, like confusing 'yes' and 'no', have been found in patients with primary progressive aphasia (PPA) but their significance for diagnosis remains unclear.
- A study analyzed data from 83 patients with different PPA types and behavioral variant frontotemporal dementia (bvFTD) to compare the occurrence of binary reversals and their diagnostic value.
- Findings showed that binary reversals were present in all nfvPPA patients, making them a strong indicator of this specific diagnosis, especially when observed early on.
Phonological processing skills have not only been shown to be important for reading skills, but also for arithmetic skills. Specifically, previous research in typically developing children has suggested that phonological processing skills may be more closely related to arithmetic problems that are solved through fact retrieval (e.g.
View Article and Find Full Text PDF