Publications by authors named "Lucy B Kim"
Article Synopsis
- * Inhibition of ATGL using the human-specific inhibitor NG497 led to an increase in lipid droplet size and number in beta cells under glucose-sufficient conditions, while in alpha cells, the effect was more pronounced under fasting conditions, indicating ATGL's role in hormone secretion in both cell types.
- * Acute inhibition of ATGL reduced glucose-stimulated insulin secretion, particularly first-phase secretion, but to a lesser extent than chronic downregulation; NG497 also significantly lowered glucagon secretion at low
Introduction: With technical advances, confocal and super-resolution microscopy have become powerful tools to dissect cellular pathophysiology. Cell attachment to glass surfaces compatible with advanced imaging is critical prerequisite but remains a considerable challenge for human beta cells. Recently, Phelps et al.
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