Publications by authors named "Lucky Jain"
Objective:: Betamethasone administration in the late preterm period(340/7–365/7 weeks’ gestation) not only reduces neonatal respiratory morbidity but also increases neonatal hypoglycemia through an uncertain mechanism. Based on data from pregnant individuals with diabetes, excessive amounts of maternal glucose can cross the placenta and cause fetal hyperinsulinemia, which can cause neonatal hypoglycemia at birth. Given that betamethasone can also increase maternal glucose levels, our objective was to explore the potential mechanisms for late preterm steroid-induced neonatal hypoglycemia by measuring the fetal metabolic effects of antenatal late preterm betamethasone and assessing the relationship of the fetal metabolic effects with neonatal hypoglycemia.
View Article and Find Full Text PDFObjective: In the antenatal late preterm steroids (ALPS) trial betamethasone significantly decreased short-term neonatal respiratory morbidity but increased the risk of neonatal hypoglycemia, diagnosed only categorically (<40 mg/dL). We sought to better characterize the nature, duration, and treatment for hypoglycemia.
Study Design: Secondary analysis of infants from ALPS, a multicenter trial randomizing women at risk for late preterm delivery to betamethasone or placebo.
Article Synopsis
- The study aimed to explore the link between clinical examination features at hospital admission and the occurrence of late preterm births in women who were in spontaneous labor at 34 to 36 weeks of pregnancy.
- A secondary analysis of a trial revealed that 59% of the 732 women studied delivered preterm, with cervical dilation and effacement measuring as key predictors of late preterm birth.
- The research concluded that including clinical factors like gestational age and nulliparity in predictions could notably enhance the accuracy of forecasting late preterm births, indicating that a significant portion of women still delivered at term despite being in late preterm labor.