Therapy of diseased stroke-prone spontaneously hypertensive rats with nimodipine.

We investigated the therapeutic effect of nimodipine or parathyroidectomy in old, diseased stroke-prone spontaneously hypertensive rats by observing 98 male 1-year-old rats over 5 months. After stroke had occurred, the rats were divided into three groups: 1) parathyroidectomy, 2) nimodipine, and 3) controls. In the nimodipine group, the rats survived longer than those in the other groups.

Induction of light hydrocarbon nephropathy by p-dichlorobenzene.

In order to clarify the etiology of a dose-related increase in the incidence of tubular cell adenocarcinomas of the kidney in male rats, the nephrotoxicity of p-dichlorobenzene (p-DCB) was investigated in a subchronic study. Groups of ten male and ten female Fischer 344 rats were dosed by gavage with 0 (controls), 75, 150, 300 or 600 mg p-DCB/kg/day in corn oil. Half of the animals were sacrificed after 4 weeks and the remainder after 13 weeks.

Salt-induced hypertension in the 'Sabra' rat strain: influence of nifedipine treatment.

The effects of chronic dietary salt-loading and nifedipine therapy on hypertension-prone (SBH), -resistant (SBN) and parental (SB) Sabra rats were investigated. Salt diet for 12 weeks resulted in a sustained hypertension and heart hypertrophy only in SBH. Nifedipine therapy (300 p.

Healing of malignant hypertensive arteriopathy in Dahl rats by nifedipine.

Pathomorphological studies were undertaken to investigate the therapeutic effect of the Ca2+-antagonist nifedipine on malignant hypertensive arteriopathy in Dahl salt-sensitive rats. The individual course of disease was followed by comparing pre-treatment biopsies of the mesenteric arteries with post-treatment findings at necropsy. Within seven weeks, continuous therapy with nifedipine resulted in healing of early vascular lesions and in partial repair of the more advanced ones.

'Calcium agonist' in salt-dependent hypertension: hints at calcium-mediated blood pressure increase.

To substantiate further the hypothesized importance of increased calcium influx into vascular smooth muscle, salt-sensitive Dahl rats (DS/JR, John Rapp), on either a low or a high salt diet, were treated with 100 or 300 ppm (i.e. mg/kg food) BAY k 8644, a calcium agonist.

Mode of antihypertensive action of nitrendipine.

The antihypertensive effect of nitrendipine cannot be explained only by its reduction of the increased peripheral vascular resistance. In contrast to the antihypertensive vasodilators, nitrendipine improves impaired renal function and prevents generalized vasculopathy in hypertensive animals. Chronic treatment with nitrendipine prevents spontaneous (Okamoto rats) and salt-induced (Dahl rats) hypertension and cardiac hypertrophy.

Calcium antagonists in hypertensive disease: experimental evidence for a new therapeutic concept.

In animal experiments calcium antagonist drugs decrease peripheral vascular resistance, improve renal sodium excretion and thus, diminishing the volume load, reduce cardiac hypertrophy. In experimental malignant hypertension these drugs preserve tissue integrity by inhibiting the deleterious calcium overload of vessels.

The granuloma pouch: an in vivo model for pharmacokinetic and chemotherapeutic investigations. II. Microbiological characterization.

In this paper we have described the microbiology of the granuloma pouch model in rats. We studied the biochemical parameters of pouch exudates infected with Escherichia coli. Data revealed that the inflammatory response increased during the course of infection since lactate dehydrogenase levels as well as alpha 2 and gamma-globulin fractions were increased in comparison to uninfected controls.

The granuloma pouch: an in vivo model for pharmacokinetic and chemotherapeutic investigations. I. Biochemical and histological characterization.

The "granuloma pouch" model in rats was evaluated on the basis of biochemical, haematological and histological factors. Seven days after formation of the pouch following the intramuscular injection of air and a mixture of 1% croton oil in olive oil as an irritant, the pouch was filled by approximately 5 ml of haemorrhagic exudate. Biochemical assessment of the exudate revealed that its main characteristics were increased lactate dehydrogenase levels as well as increased alpha 2- and gamma-globulin fractions.

Prevention of hypertensive vasculopathy by nifedipine in salt-loaded Dahl rats.

In female "salt-sensitive" (S) Dahl rats, with hypertension induced by 8% sodium chloride (NaCl) in the diet for six weeks, a severe generalized arteriopathy was observed histopathologically. Fibrinoid degeneration, medial hyperplasia and periarteritis were especially pronounced in the preglomerular arterial system of the kidneys. Necrosis of afferent glomerular arterioles led to regressive changes in the renal corpuscles.

Study by fluorescence microscopy of the effect of fluorescent whitening agents on the skin of mice.

Fluorescence microscopic studies of the skin of hairless mice showed that a fluorescent whitening agent (FWA) of the bis(phenyltriazolyl)stilbenedisulfonate type did not penetrate into the subepithelial layers (dermis and subcutaneous tissue) of the skin after cutaneous application.