Predictors of microvascular complications in type 1 diabetic patients at onset: the role of metabolic memory.

Background: Several epidemiological studies showed a close association between metabolic control and microvascular complications in type 1 Diabetes Mellitus (T1DM). The aim of our longitudinal observational study was to evaluate the predictive role of the main clinical and biochemical parameters in determining microvascular complications.

Methods: 376 T1DM patients, hospitalized in our division from 1991 to 2005 (mean follow-up=10.