Publications by authors named "Lucilia Pereira Dutra-Molina"
Article Synopsis
- - Household contacts of pulmonary tuberculosis (TB) patients are at a higher risk of infection and disease, and this study aimed to understand the relationship between exposure intensity and risk levels.
- - Conducted in Vitória, Brazil, the study included 160 TB patients and 894 household contacts, finding that 65% had TB infection and 2.6% developed TB disease, with risk increasing alongside exposure intensity.
- - Although increased proximity to TB cases raised the likelihood of infection and disease, the current methods to assess risk were only moderately effective, highlighting the need for a better biomarker to identify those who could benefit from preventive therapy.
Background: In household contact investigations of tuberculosis (TB), a second tuberculin skin test (TST) obtained several weeks after a first negative result consistently identifies individuals that undergo TST conversion. It remains unclear whether this delay in M. tuberculosis infection is related to differences in the infectious exposure, TST boosting, partial host resistance, or some other factor.
View Article and Find Full Text PDFRationale: The degree to which tuberculosis (TB) is transmitted between persons is variable. Identifying the factors that contribute to transmission could provide new opportunities for TB control. Transmission is influenced by host, bacterial and environmental factors.
View Article and Find Full Text PDFObjective: To compare clinical, radiological and laboratory aspects of household contacts, aged 15 or younger, of patients presenting a positive culture for Mycobacterium tuberculosis.
Methods: This was a cohort study comparing children and adolescents (< or = 15 years of age) who were household contacts of TB cases presenting positive sputum smear and positive culture results (exposed group, n = 100) or negative sputum smear and positive culture results (unexposed group, n = 55). All of the contacts were evaluated via the TB control program of a university hospital in the city of Vitória, Brazil, between July of 2003 and December of 2006.