Publications by authors named "Lucile Garrigues"
Tetanus vaccination is of major importance for public health in most countries in the world. The World Health Organization indicated that 15,000 tetanus cases were reported in 2018 (Organization, World Health, 2019). Currently, vaccine manufacturers use tetanus toxin produced by Clostridium tetani fermentation in complex media.
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- A bioreactor was created to enhance gas mass transfer, allowing engineered autotrophic strains to reach cell and product concentrations in the gram per liter range using CO as a carbon source.
- The bioreactor supports separate inputs for CO, H, and air, and can operate at high pressures without harming the viability of the Cupriavidus necator strains.
- An engineered strain produced 3.5 g/L of isopropanol solely from CO, marking a significant advancement in CO-based bioprocesses.