Publications by authors named "Lucien Lecuyer"
Article Synopsis
- A prospective study was conducted to examine the association between three specific circulating microRNAs (10a, 92a, 155) and cardiac rejection in heart transplant recipients across 11 centers from August 2016 to March 2018.
- The study involved 461 patients and 831 biopsies, of which 79 indicated rejection; however, the interim analysis found no significant association between the microRNAs and rejection diagnosis.
- Ultimately, the research concluded that monitoring these microRNAs does not provide clinical utility for heart transplant recipients, leading to the decision to halt further analysis for futility.
Background: As an increasing number of deaths occur in the intensive care unit (ICU), studies have sought to describe, understand, and improve end-of-life care in this setting. Most of these studies are centered on the patient's and/or the relatives' experience. Our study aimed to develop an instrument designed to assess the experience of physicians and nurses of patients who died in the ICU, using a mixed methodology and validated in a prospective multicenter study.
View Article and Find Full Text PDFArticle Synopsis
- - Belatacept (BTC) is used to prevent graft rejection in kidney transplant patients and was studied in heart transplant recipients from January 2014 to October 2018, focusing on its impact on renal function and safety.
- - Among 40 patients, those who started BTC within the first 3 months showed a significant improvement in kidney function (GFR increased by 59% within a month), while late starters faced more rejection episodes.
- - The study noted a 76% rate of changes in immunosuppressive therapy, primarily to conserve kidney function, with a median follow-up of 24 months, indicating BTC's effectiveness but also highlighting complications like DSA development and treatment discontinuations.
Hepatitis E virus (HEV) can induce chronic infections in the case of immunosuppression, which are sometimes not cured with ribavirin. Furthermore, sofosbuvir is a highly potent inhibitor of HCV polymerase and was shown to inhibit HEV genotype-3 replication in vitro. We report here the outcome of sofosbuvir/ribavirin therapy on a chronic HEV infection in a heart transplant recipient non-responder to ribavirin.
View Article and Find Full Text PDFAppropriate exposure to posaconazole (PSZ) has been limited until the recent approval of the delayed-release oral tablet formulation. Our goal was to determine the exposure obtained by using the standard dose of 300 mg once a day in lung transplant (LT) patients, including patients with cystic fibrosis (CF). PSZ trough concentrations () were determined using a liquid chromatography-tandem mass spectrometry assay.
View Article and Find Full Text PDFBackground: Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP).
Methods: This was an observational study of patients with VZV-CAP admitted to 29 intensive care units (ICUs) from January 1996 to January 2015.
Purpose: To develop an instrument designed specifically to assess the experience of relatives of patients who die in the intensive care unit (ICU).
Methods: The instrument was developed using a mixed methodology and validated in a prospective multicentre study. Relatives of patients who died in 41 ICUs completed the questionnaire by telephone 21 days after the death, then completed the Hospital Anxiety and Depression Scale, Impact of Event Scale-Revised and Inventory of Complicated Grief after 3, 6, and 12 months.
An increased proportion of deaths occur in the intensive care unit (ICU). We performed this prospective study in 41 ICUs to determine the prevalence and determinants of complicated grief after death of a loved one in the ICU. Relatives of 475 adult patients were followed up.
View Article and Find Full Text PDFPurpose: To describe laryngeal injuries after intubation in an intensive care unit and assess their risk factors and their association with post-extubation stridor (PES) and extubation failure.
Methods: Prospective study including 136 patients extubated after more than 24 h of mechanical ventilation. Fiberoptic endoscopic examination of the larynx was systemically performed within 6 h after extubation in order to record four types of laryngeal anomalies: edema, ulceration, granulation, and abnormal vocal cord (VC) mobility.
Background: Stent deployment within stenotic native aortic valves has been shown to depend on valve anatomy (presence of bicuspid valve or not). This study investigated the influence of stent stiffness on stent expansion.
Methods: The study included 88 patients with severe aortic stenosis, and 36 (41%) had bicuspid aortic valves.
Objective: Cancer patients requiring mechanical ventilation are widely viewed as poor candidates for intensive care unit (ICU) admission. We designed a prospective study evaluating a new admission policy titled The ICU Trial.
Design: Prospective study.
Objective: To evaluate the usefulness of B-type natriuretic peptide and troponin I measurements in predicting right ventricular dysfunction (RVD) in non-massive pulmonary embolism.
Design: Prospective observational study.
Setting: University-affiliated emergency unit, cardiology and pneumology departments.
Objective: HemoCue is routinely used to manage bleeding patients, but few studies have evaluated its accuracy in this population. We compared HemoCue with laboratory determination of blood hemoglobin in patients with gastrointestinal bleeding.
Design And Setting: A prospective observational study in a 14-bed medicosurgical ICU and an emergency department in an urban general hospital.