Chemosensitivity of BRCA1-Mutated Ovarian Cancer Cells and Established Cytotoxic Agents.

Objective: Serous adenocarcinomas that arise in patients with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 are initially well treatable with platinum/paclitaxel. For recurrent disease in patients with BRCA1 or BRCA2 mutations, olaparib treatment is available. To study additional therapeutic regimens, a better understanding of the cellular and molecular mechanisms of the tumors in in vitro models is important.

[Uterine fibroids complicated by haematometra].

Background: Uterine fibroids are common, benign tumours of the myometrium. The clinical symptoms include menorrhagia, abdominal pain and subfertility.

Case Description: A 37-year-old black woman known to have uterine fibroids presented at the gynaecology outpatient clinic with abdominal pain.

MRI for clinically suspected appendicitis during pregnancy.

Objective: The purpose of this study was to evaluate whether MRI can be used to accurately diagnose or exclude appendicitis in pregnant patients with clinically suspected appendicitis.

Conclusion: Our results suggest that MRI is helpful in the examination and diagnosis of acute appendicitis in pregnant patients. MRI may therefore be a good alternative to CT in pregnant patients for whom sonographic findings are nondiagnostic.