Publications by authors named "Lucie Rebel"
Endoscopic prophylactic nipple-sparing mastectomy: First French survey of 10 patients.
J Gynecol Obstet Hum Reprod
January 2025
Article Synopsis
- The study evaluates the feasibility and safety of the Endoscopic Nipple Sparing Mastectomy (E-NSM) technique for women at high risk of breast cancer, focusing on performing the surgery with minimal incisions and immediate reconstruction.
- A total of 10 patients underwent the procedure with a complete success rate, showing only a small percentage of complications, primarily minor issues like skin necrosis and hematomas.
- Patients reported high satisfaction with the esthetic results, leading to a recommendation for the technique; however, further research involving a larger patient group is needed for validation.
Article Synopsis
- A study analyzed the relationship between the volume of ovarian cancer surgeries at hospitals in France and patient outcomes, focusing on data from 2012 to 2016.
- It included 8429 patients and found that those treated in hospitals performing at least 20 surgeries per year had better 5-year overall survival (OS) rates compared to those in lower-volume hospitals.
- The findings indicate that high-volume hospitals (≥ 20 cases/year) are linked to improved patient outcomes, particularly when compared to hospitals performing fewer than 10 surgeries per year, highlighting the importance of surgical experience in treating ovarian cancer.
Article Synopsis
- Platinum salts like oxaliplatin are used in HIPEC for treating digestive tract cancers, but their effects on ovarian function during treatment raise concerns, especially for young women.
- Advanced mass spectrometry imaging techniques, specifically MALDI-MS and LA-ICP MS, were utilized to examine how oxaliplatin penetrates ovaries post-HIPEC therapy.
- Findings indicated that oxaliplatin and elemental platinum were localized in the ovaries, with more extensive diffusion in patients who had prior platinum-based chemotherapy, highlighting potential gonadal toxicity risks.
Article Synopsis
- Preoperative localization techniques for occult breast cancer, such as radioisotopic localization and wire localization, can be invasive and uncomfortable; a new virtual localization method was evaluated in this study.
- The study involved nine patients from 2016 to 2017 who had radioisotopic localization combined with preoperative prone MRI and intraoperative 3D optical scanning to improve tumor localization.
- The results showed successful tumor localization with a distance of 1.4 cm in patients with small breasts and 2.8 cm in larger breasts; further optimization and the potential addition of augmented reality could improve this noninvasive technique for future studies.