Publications by authors named "Lucie Moss"
Article Synopsis
- Schistosomiasis affects over 250 million people globally and causes significant health issues, including intestinal hemorrhage and liver problems due to the Schistosoma mansoni parasite.
- A study using a mouse model investigated how this infection impacts platelets, finding changes in platelet surface markers and spontaneous aggregation despite prolonged blood coagulation times.
- These findings suggest that chronic schistosomiasis can affect blood clotting, which may be important for understanding health risks in affected populations.
Thrombopoietin (THPO or TPO) is an essential cytokine for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Here, we report the 3.4 Å resolution cryoelectron microscopy structure of the extracellular TPO-TPO receptor (TpoR or MPL) signaling complex, revealing the basis for homodimeric MPL activation and providing a structural rationalization for genetic loss-of-function thrombocytopenia mutations.
View Article and Find Full Text PDFRecent advances in the understanding of depression have led to increasing interest in ketamine and the role that -methyl-d-aspartate (NMDA) receptor inhibition plays in depression. l-4-Chlorokynurenine (4-Cl-KYN, AV-101), a prodrug, has shown promise as an antidepressant in preclinical studies, but this promise has not been realized in recent clinical trials. We sought to determine if transporters in the CNS could be playing a role in this clinical response.
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