Publications by authors named "Lucie Lecouflet"
Article Synopsis
- Ovarian cancer, a leading cause of gynecological cancer deaths, often becomes resistant to chemotherapy, highlighting the urgency for new treatment approaches and predictive biomarkers.
- The OVAREX study investigates the feasibility of creating patient-derived tumor models (like PDX, PDTO, and ADS) to predict clinical outcomes for ovarian cancer patients undergoing treatment.
- This research aims to validate the predictive capabilities of these models by comparing their responses to treatments with actual patient outcomes, potentially enhancing clinical decision-making.
Background: For the last 40 years, the technique of extracorporeal photopheresis (ECP) has constantly developed. Among irradiation systems, those called "off-line" allow the validation of the quality of the cell therapy product. The inhibition of the proliferation of lymphocytes after ultraviolet irradiation (UVA) is usually verified by the tritiated thymidine assay as in vitro proliferation assay.
View Article and Find Full Text PDFBackground: For the last 40 years, the technique of extracorporeal photopheresis has constantly developed. Among irradiation systems, those called 'off-line' allow the validation of the quality of the cell therapy product. The inhibition of the proliferation of lymphocytes after UVA irradiation is usually verified by the tritiated thymidine assay as in vitro proliferation assay.
View Article and Find Full Text PDF