Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials.

Objective: To re-assess the effect of tight glycaemic control on diabetic microvascular complications.

Method: Meta-analysis and trial sequential analyses of randomised trials included in Hemmingsen et al that specifically assessed glycaemic control with a specific HbA level targeted in the intervention group, and compared intensive glycaemic control versus standard glycaemic control.

Results: Seven clinical trials that randomised 28,614 participants with type 2 diabetes (15,269 to intensive control and 13,345 to conventional control), including 3 sub-studies, were included.