Publications by authors named "Lucie Friedova"

Background: An association between lipid measures and cognitive decline in patients with multiple sclerosis (MS) has been suggested.

Objectives: This study aimed to investigate relationships between lipid profile and cognitive performance in a large observational cohort of MS patients.

Materials And Methods: We included 211 patients with 316 available pairs of lipid and cognitive measures performed over follow-up.

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Background: Early diagnosis and treatment of patients with multiple sclerosis (MS) are associated with better outcomes; however, diagnostic delays remain a major problem.

Objective: Describe the prevalence, determinants and consequences of delayed diagnoses.

Methods: This single-centre ambispective study analysed 146 adult relapsing-remitting MS patients (2016-2021) for frequency and determinants of diagnostic delays and their associations with clinical, cognitive, imaging and biochemical measures.

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Background: Although there is evidence that shows worse cognitive functioning in male patients with multiple sclerosis (MS), the role of brain pathology in this context is under-investigated.

Objective: To investigate sex differences in cognitive performance of MS patients, in the context of brain pathology and disease burden.

Methods: Brain MRI, neurological examination, neuropsychological assessment (Brief International Cognitive Assessment in MS-BICAMS, and Paced Auditory Verbal Learning Test-PASAT), and patient-reported outcome questionnaires were performed/administered in 1052 MS patients.

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Background: Impairment of higher language functions associated with natural spontaneous speech in multiple sclerosis (MS) remains underexplored.

Objectives: We presented a fully automated method for discriminating MS patients from healthy controls based on lexical and syntactic linguistic features.

Methods: We enrolled 120 MS individuals with Expanded Disability Status Scale ranging from 1 to 6.

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Dysphagia is a common symptom of neurological disease, including multiple sclerosis (MS). The DYsphagia in MUltiple Sclerosis (DYMUS) questionnaire was developed as a screening tool for swallowing problems. The purpose of the present study was to validate the Czech version of the DYMUS questionnaire.

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Background: Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in patients with multiple sclerosis (MS). The role of diffuse spinal cord lesions remains less understood. The purpose of this study was to evaluate focal and especially diffuse spinal cord lesions in patients with early relapsing-remitting MS and their association with intracranial lesion topography, global and regional brain volume, and spinal cord volume.

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Purpose: To identify the clinical and paraclinical markers of employment status in multiple sclerosis (MS).

Methods: This was a cross-sectional sub-study investigating 1226 MS patients. To minimalized confounding effect, two groups of patients, matched by sex, age, and education, were selected: 307 patients with full time employment and 153 unemployed patients receiving disability pension.

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(1) Background: Cognitive deterioration is an important marker of disease activity in multiple sclerosis (MS). It is vital to detect cognitive decline as soon as possible. Cognitive deterioration can take the form of isolated cognitive decline (ICD) with no other clinical signs of disease progression present.

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Background: Neurofilament light chain level in serum (sNfL) and cerebrospinal fluid (CSF-NfL) is a promising biomarker of disease activity in multiple sclerosis (MS). However, predictive value of neurofilaments for development of cognitive decline over long-term follow-up has not been extensively studied.

Objective: To investigate the relationship between early neurofilament levels and cognitive performance after 9-years.

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Spinal cord (SC) pathology is strongly associated with disability in multiple sclerosis (MS). We aimed to evaluate the association between focal and diffuse SC abnormalities and spinal cord volume and to assess their contribution to physical disability in MS patients. This large sample-size cross-sectional study investigated 1,249 patients with heterogeneous MS phenotypes.

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Although dysarthria is a common pattern in multiple sclerosis (MS), the contribution of specific brain areas to key factors of dysarthria remains unknown. Speech data were acquired from 123 MS patients with Expanded Disability Status Scale (EDSS) ranging from 1 to 6.5 and 60 matched healthy controls.

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Background: Impairment of cognition and speech are common in multiple sclerosis (MS) patients, but their relationship is not well understood.

Objective: To describe the relationship between articulation rate characteristics and processing speed and to investigate the potential role of objective speech analysis for the detection of cognitive decline in MS.

Methods: A total of 122 patients with clinically definite MS were included in this cross-sectional pilot study.

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