Publications by authors named "Lucie Chambon"
Article Synopsis
- Mycophenolic acid (MPA) is a key treatment for systemic lupus erythematosus (SLE), and its effectiveness is enhanced by monitoring drug levels using the area under the curve (AUC).
- Recent studies have used complex population pharmacokinetics models to analyze MPA absorption, but new approaches using non-linear mixed effect (NLME) models with stochastic approximation algorithms had not been explored before.
- This study aimed to implement a double absorption gamma model in Monolix, compare various absorption models for MPA, and create a limited sampling strategy to reliably estimate AUC in pediatric SLE patients.
For coupled oscillator networks with Laplacian coupling, the master stability function (MSF) has proven a particularly powerful tool for assessing the stability of the synchronous state. Using tools from group theory, this approach has recently been extended to treat more general cluster states. However, the MSF and its generalizations require the determination of a set of Floquet multipliers from variational equations obtained by linearization around a periodic orbit.
View Article and Find Full Text PDF