Publications by authors named "Lucie Capelle"

Haematopoietic stem cell collection from paediatric donors is a common and life-saving practice, as evidenced by the fact that there is a growing annual number of cases of transplants from minor donors among SFGM-TC centers over the last decade. Still, medical use of human tissue from a healthy and underage donor requires proper regulations and medical management. The guidelines below aim at underlining the importance of pondering the legal, medical and ethical aspects of using stem cells from healthy paediatric donors and stress out the importance of obtaining informed consent at the time of assessing HLA compatibility.

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Article Synopsis
  • The French health authorities established guidelines for "good transfusion practices," but there is limited guidance for managing transfusions in patients who have undergone allogeneic hematopoietic stem transplantation (allo-HCT).
  • A workshop aimed to standardize transfusion practices for this patient group where recommendations are lacking.
  • Key recommendations include conducting extended blood cell phenotyping before transplantation, monitoring antibody levels, and assessing chimerism at specific intervals post-transplant to adjust transfusion strategies as needed.
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Since patients require multiple intravenous drugs, drug incompatibilities and drug interactions are frequent during the acute phase following hematopoietic cell transplantation. The risk of drug-drug interactions is increased in patients with several comorbidities. The goal of this workshop was to learn how to mitigate the risks of drug incompatibilities and interactions when their usage is therapeutically warranted.

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